AIMC Topic: Computational Biology

Clear Filters Showing 631 to 640 of 4399 articles

DeepEnhancerPPO: An Interpretable Deep Learning Approach for Enhancer Classification.

International journal of molecular sciences
Enhancers are short genomic segments located in non-coding regions of the genome that play a critical role in regulating the expression of target genes. Despite their importance in transcriptional regulation, effective methods for classifying enhance...

Accurate prediction of colorectal cancer diagnosis using machine learning based on immunohistochemistry pathological images.

Scientific reports
Colorectal cancer (CRC) ranks as the third most prevalent tumor and the second leading cause of mortality. Early and accurate diagnosis holds significant importance in enhancing patient treatment and prognosis. Machine learning technology and bioinfo...

Parallel development of object recognition in newborn chicks and deep neural networks.

PLoS computational biology
How do newborns learn to see? We propose that visual systems are space-time fitters, meaning visual development can be understood as a blind fitting process (akin to evolution) in which visual systems gradually adapt to the spatiotemporal data distri...

Identification of an immune-related gene panel for the diagnosis of pulmonary arterial hypertension using bioinformatics and machine learning.

International immunopharmacology
OBJECTIVE: This study aimed to screen an immune-related gene (IRG) panel and develop a novel approach for diagnosing pulmonary arterial hypertension (PAH) utilizing bioinformatics and machine learning (ML).

Annotation Practices in Computational Pathology: A European Society of Digital and Integrative Pathology (ESDIP) Survey Study.

Laboratory investigation; a journal of technical methods and pathology
Integrating digital pathology and artificial intelligence (AI) algorithms can potentially improve diagnostic practice and precision medicine. Developing reliable, generalizable, and comparable AI algorithms depends on access to meticulously annotated...

Synthetic augmentation of cancer cell line multi-omic datasets using unsupervised deep learning.

Nature communications
Integrating diverse types of biological data is essential for a holistic understanding of cancer biology, yet it remains challenging due to data heterogeneity, complexity, and sparsity. Addressing this, our study introduces an unsupervised deep learn...

Robust parameter estimation and identifiability analysis with hybrid neural ordinary differential equations in computational biology.

NPJ systems biology and applications
Parameter estimation is one of the central challenges in computational biology. In this paper, we present an approach to estimate model parameters and assess their identifiability in cases where only partial knowledge of the system structure is avail...

Special Issue "Machine Learning and Bioinformatics in Human Health and Disease"-Chances and Challenges.

International journal of molecular sciences
Machine learning (ML) and bioinformatics are catalyzing a new era in biomedical research, enabling unprecedented insights into the complex systems that govern human health and disease [...].

Identification of immune-related mitochondrial metabolic disorder genes in septic shock using bioinformatics and machine learning.

Hereditas
PURPOSE: Mitochondria are involved in septic shock and inflammatory response syndrome, which severely affects the life security of patients. It is necessary to recognize and explore the immune-mitochondrial genes in septic shock.

Multi-omics characterization and machine learning of lung adenocarcinoma molecular subtypes to guide precise chemotherapy and immunotherapy.

Frontiers in immunology
BACKGROUND: Lung adenocarcinoma (LUAD) is a heterogeneous tumor characterized by diverse genetic and molecular alterations. Developing a multi-omics-based classification system for LUAD is urgently needed to advance biological understanding.