AIMC Topic: Crohn Disease

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Pre-Treatment Biomarkers of Anti-Tumour Necrosis Factor Therapy Response in Crohn's Disease-A Systematic Review and Gene Ontology Analysis.

Cells May 28, 2019
The most prominent treatment for the serious cases of Crohn's disease (CD) are biological tumour necrosis factor (TNF) inhibitors. Unfortunately, therapy nonresponse is still a serious issue in ~1/3 of CD patients. Accurate prediction of responsivene...
Humans Tumor Necrosis Factor-alpha Biomarkers Gene Ontology Polymorphism, Single Nucleotide Crohn Disease RNA Genome, Human
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Development and Validation of Machine Learning Models in Prediction of Remission in Patients With Moderate to Severe Crohn Disease.

JAMA network open May 3, 2019
IMPORTANCE: Biological therapies have revolutionized inflammatory bowel disease management, but many patients do not respond to biological monotherapy. Identification of likely responders could reduce costs and delays in remission.
Ustekinumab Adult Male Middle Aged Severity of Illness Index Crohn Disease Remission Induction Biological Therapy Predictive Value of Tests Humans C-Reactive Protein Machine Learning Female
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Infliximab trough levels and persistent vs transient antibodies measured early after induction predict long-term clinical remission in patients with inflammatory bowel disease.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Nov 27, 2017
BACKGROUND: The use of therapeutic drug monitoring has been proposed as a useful tool in the management of patients with loss of response to biological therapy in patients with inflammatory bowel disease.
Time Factors ROC Curve Colitis, Ulcerative Drug Monitoring Antibodies Remission Induction Infliximab Drug Resistance Crohn Disease Gastrointestinal Agents Young Adult Humans Adult Prospective Studies Male Female Middle Aged Aged
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An empirical fuzzy multifactor dimensionality reduction method for detecting gene-gene interactions.

BMC genomics Mar 14, 2017
BACKGROUND: Detection of gene-gene interaction (GGI) is a key challenge towards solving the problem of missing heritability in genetics. The multifactor dimensionality reduction (MDR) method has been widely studied for detecting GGIs. MDR reduces the...
Bipolar Disorder Polymorphism, Single Nucleotide Genotype Models, Genetic Humans Software Epistasis, Genetic Multifactor Dimensionality Reduction Fuzzy Logic Internet Crohn Disease Datasets as Topic
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Bayesian Machine Learning Techniques for revealing complex interactions among genetic and clinical factors in association with extra-intestinal Manifestations in IBD patients.

AMIA ... Annual Symposium proceedings. AMIA Symposium Feb 10, 2017
The objective of the study is to assess the predictive performance of three different techniques as classifiers for extra-intestinal manifestations in 152 patients with Crohn's disease. Naïve Bayes, Bayesian Additive Regression Trees and Bayesian Net...
Algorithms Female Risk Factors Male Humans Machine Learning Data Mining Polymorphism, Genetic Genetic Predisposition to Disease Models, Statistical Bayes Theorem Crohn Disease
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Effect of fuzzy partitioning in Crohn's disease classification: a neuro-fuzzy-based approach.

Medical & biological engineering & computing Apr 22, 2016
Crohn's disease (CD) diagnosis is a tremendously serious health problem due to its ultimately effect on the gastrointestinal tract that leads to the need of complex medical assistance. In this study, the backpropagation neural network fuzzy classifie...
Fuzzy Logic Crohn Disease Humans Neural Networks, Computer ROC Curve
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Vitamin D status in relation to Crohn's disease: Meta-analysis of observational studies.

Nutrition (Burbank, Los Angeles County, Calif.) Dec 22, 2015
OBJECTIVES: Inconsistent findings have been published regarding vitamin D status among patients with Crohn's disease (CD) and the association with disease severity. We aimed to perform a meta-analysis evaluating serum 25-hydroxy vitamin D and 1,25 de...
Severity of Illness Index Child Vitamin D Deficiency Observational Studies as Topic Evidence-Based Medicine Sunlight 25-Hydroxyvitamin D 2 Crohn Disease Nutritional Status Humans Adult Global Health Prevalence
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Serum Interleukin-33 level in Saudi children with inflammatory bowel disease.

International journal of clinical and experimental pathology Dec 1, 2015
Interleukin-33 (IL-33) is a cytokine that belongs to the interleukin-1 family and has been shown to be associated with mucosal inflammation. The aim of this study was to determine the serum level of IL-33 in children with ulcerative colitis (UC) and ...
Child Enzyme-Linked Immunosorbent Assay Age Factors Biological Products Predictive Value of Tests C-Reactive Protein Crohn Disease Severity of Illness Index Colitis, Ulcerative Prognosis Case-Control Studies Diagnosis, Differential Saudi Arabia Female Humans Inflammation Mediators Adolescent Cross-Sectional Studies Prospective Studies Up-Regulation Male Biomarkers Nephelometry and Turbidimetry Interleukin-33
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Seasonal variation in onset and relapse of IBD and a model to predict the frequency of onset, relapse, and severity of IBD based on artificial neural network.

International journal of colorectal disease May 15, 2015
BACKGROUND: Previous research has yielded conflicting data as to whether the natural history of inflammatory bowel disease follows a seasonal pattern. The purpose of this study was (1) to determine whether the frequency of onset and relapse of inflam...
Incidence Colitis, Ulcerative Crohn Disease Weather Seasons Recurrence Adult Male Middle Aged Severity of Illness Index Humans Neural Networks, Computer Forecasting Female
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Vedolizumab in inflammatory bowel disease: Real-world outcomes and their prediction with machine learning-the IG-IBD LIVE study.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Jul 1, 2025
BACKGROUND AND AIMS: Real-world studies on vedolizumab in inflammatory bowel disease (IBD) are often limited by small sample size and short follow-up. In this study, we investigated the 2-year effectiveness and safety of vedolizumab in patients with ...
Female Aged Young Adult Adult Humans Machine Learning Inflammatory Bowel Diseases Colitis, Ulcerative Italy Crohn Disease Gastrointestinal Agents Remission Induction Male Middle Aged Treatment Outcome Antibodies, Monoclonal, Humanized
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