AIMC Topic: DNA

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Deep learning to predict the lab-of-origin of engineered DNA.

Nature communications Aug 7, 2018
Genetic engineering projects are rapidly growing in scale and complexity, driven by new tools to design and construct DNA. There is increasing concern that widened access to these technologies could lead to attempts to construct cells for malicious i...
Neural Networks, Computer Software Mutation Synthetic Biology Plasmids Genetic Engineering Deep Learning Image Processing, Computer-Assisted DNA Bayes Theorem
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Automation of the Differential Digestion Process of Sexual Assault Evidence.

Journal of forensic sciences Jul 25, 2018
Sexual assault evidence samples require the use of a specific process known as a differential digestion to separate sperm from nonsperm cells prior to DNA extraction. An automated differential digestion process was developed using a selective degrada...
Humans DNA Semen Automation Forensic Sciences Female Male Real-Time Polymerase Chain Reaction Robotics Microsatellite Repeats DNA Fingerprinting Deoxyribonuclease I Sex Offenses Specimen Handling Indicators and Reagents Cell Separation
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EL_LSTM: Prediction of DNA-Binding Residue from Protein Sequence by Combining Long Short-Term Memory and Ensemble Learning.

IEEE/ACM transactions on computational biology and bioinformatics Jul 23, 2018
Most past works for DNA-binding residue prediction did not consider the relationships between residues. In this paper, we propose a novel approach for DNA-binding residue prediction, referred to as EL_LSTM, which includes two main components. The fir...
Machine Learning Algorithms Computational Biology Databases, Protein DNA DNA-Binding Proteins Binding Sites
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Scaling up molecular pattern recognition with DNA-based winner-take-all neural networks.

Nature Jul 4, 2018
From bacteria following simple chemical gradients to the brain distinguishing complex odour information, the ability to recognize molecular patterns is essential for biological organisms. This type of information-processing function has been implemen...
Pattern Recognition, Automated Memory Models, Neurological DNA Neurons Neural Networks, Computer
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GeNets: a unified web platform for network-based genomic analyses.

Nature methods Jun 18, 2018
Functional genomics networks are widely used to identify unexpected pathway relationships in large genomic datasets. However, it is challenging to compare the signal-to-noise ratios of different networks and to identify the optimal network with which...
Internet RNA Databases, Nucleic Acid Genomics Nucleic Acid Amplification Techniques DNA Machine Learning Software
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A DNA Nanorobot Uprises against Cancer.

Trends in molecular medicine May 22, 2018
DNA-based nanorobots have been shown to sense and respond to molecular triggers, such as intracellular pH and cell surface receptors. A recent report describes DNA nanorobots as potential cancer therapeutic agents that can be programmed to trigger co...
Humans Neoplasms Robotics DNA
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DPP-PseAAC: A DNA-binding protein prediction model using Chou's general PseAAC.

Journal of theoretical biology May 16, 2018
A DNA-binding protein (DNA-BP) is a protein that can bind and interact with a DNA. Identification of DNA-BPs using experimental methods is expensive as well as time consuming. As such, fast and accurate computational methods are sought for predicting...
Protein Domains Amino Acids DNA-Binding Proteins Amino Acid Sequence Nucleic Acid Conformation Support Vector Machine Databases, Protein DNA Models, Molecular Algorithms Reproducibility of Results Computational Biology
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High-Order Convolutional Neural Network Architecture for Predicting DNA-Protein Binding Sites.

IEEE/ACM transactions on computational biology and bioinformatics Mar 26, 2018
Although Deep learning algorithms have outperformed conventional methods in predicting the sequence specificities of DNA-protein binding, they lack to consider the dependencies among nucleotides and the diverse binding lengths for different transcrip...
Neural Networks, Computer Software DNA-Binding Proteins Binding Sites Amino Acid Motifs Algorithms Computational Biology Chromatin Immunoprecipitation Protein Binding Transcription Factors Genomics Area Under Curve DNA
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Key Clinical Factors Predicting Adipokine and Oxidative Stress Marker Concentrations among Normal, Overweight and Obese Pregnant Women Using Artificial Neural Networks.

International journal of molecular sciences Dec 28, 2017
Maternal obesity has been related to adverse neonatal outcomes and fetal programming. Oxidative stress and adipokines are potential biomarkers in such pregnancies; thus, the measurement of these molecules has been considered critical. Therefore, we d...
Adiponectin Gestational Age Resistin Pregnancy Trimester, Third Humans Deoxyguanosine Neural Networks, Computer Gene Expression Biomarkers Case-Control Studies 8-Hydroxy-2'-Deoxyguanosine Oxidative Stress Protein Carbonylation Pregnancy Malondialdehyde Leptin Female Age Factors Body Mass Index Adult Obesity Severity of Illness Index DNA
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Association Between Genotypes and Risk of Cardiovascular Disease in MESA (Multi-Ethnic Study of Atherosclerosis).

Journal of the American Heart Association Dec 21, 2017
BACKGROUND: genetic variants confer an increased risk for kidney disease. Their associations with cardiovascular disease (CVD) are less certain. We aimed to compare the prevalence of subclinical CVD and incidence of atherosclerotic CVD and heart fai...
Mutation, Missense Ethnicity DNA Mutational Analysis Apolipoprotein L1 Cardiovascular Diseases Aged Humans Incidence Middle Aged Aged, 80 and over Female Prevalence Cross-Sectional Studies Genotype Risk Factors DNA Male Atherosclerosis
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