BACKGROUND: Alzheimer's disease and related dementias (ADRDs) are being diagnosed at epidemic rates, with incidence to triple from 35 to 115 million cases worldwide. Most ADRDs are characterized by progressive neurodegeneration, and Alzheimer's disea...
The journal of prevention of Alzheimer's disease
Jan 1, 2019
BACKGROUND: Recruiting patients for clinical trials of potential therapies for Alzheimer's disease (AD) remains a major challenge, with demand for trial participants at an all-time high. The AD treatment R and D pipeline includes around 112 agents. I...
Osteoarthritis (OA) is an extremely common musculoskeletal disease. However, current guidelines are not well suited for diagnosing patients in the early stages of disease and do not discriminate patients for whom the disease might progress rapidly. T...
Annals of the American Thoracic Society
Dec 1, 2018
Despite being a major cause of morbidity and mortality, chronic obstructive pulmonary disease (COPD) is frequently undiagnosed. Yet the burden of disease among the undiagnosed is significant, as these individuals experience symptoms, exacerbations, a...
Journal of the American Medical Informatics Association : JAMIA
Aug 1, 2018
BACKGROUND: Existing screening tools for early detection of autism are expensive, cumbersome, time- intensive, and sometimes fall short in predictive value. In this work, we sought to apply Machine Learning (ML) to gold standard clinical data obtaine...
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Jul 1, 2018
Electroencephalogram (EEG) signal based early diagnosis of Alzheimer's Disease (AD), especially a discrimination between healthy control (HC) and mild cognitive impairment (MCI) has received remarkable attentions to complement conventional diagnosing...
BACKGROUND: This study aimed to determine whether the back-propagation artificial neural network (BP-ANN) model could be constructed to accurately in predicting early occlusion of bilateral plastic stent placement for inoperable hilar cholangiocarcin...