Thirty to seventy percent of proteins in any given genome have no assigned function and have been labeled as the protein "unknome." This large knowledge shortfall is one of the final frontiers of biology. Machine learning (ML) approaches are enticing...
Bacterial infectious diseases pose significant challenges to public health, emphasizing the need for rapid and accurate diagnostic tools. Here, we introduced a multichannel fluorescent sensor array based on antimicrobial peptide-functionalized gold n...
The environment of underwater salvage is very special, and many factors such as real-time water conditions, the depth of salvage, and the complexity of underwater conditions could greatly affect the smooth progress of the salvage process. How to accu...
Point-of-Care Testing (POCT) is rapidly increasing, providing quick, user-friendly, and portable diagnostic tools. Lateral flow assays (LFAs) have been central to POCT, administering fast and cost-effective diagnosis. However, traditional LFAs are li...
Escherichia coli recovered from dogs with clinical conditions such as urinary tract infections are often used to assess populations for resistance to critically important antimicrobials (CIAs). Despite the potential importance of such strains, the nu...
Small regulatory RNAs (sRNAs) are widespread in bacteria. However, characterizing the targets of sRNA regulation in a way that scales with the increasing number of identified sRNAs has proven challenging. Computational methods offer one means for eff...
In order to improve predictability of outcome and reduce costly rounds of trial-and-error, machine learning models have been of increasing importance in the field of synthetic biology. Besides applications in predicting genome annotation, process par...
Bacterial small RNAs (sRNAs) are pivotal in post-transcriptional regulation, affecting functions like virulence, metabolism, and gene expression by binding specific mRNA targets. Identifying these targets is crucial to understanding sRNA regulation a...
The arginine dihydrolase pathway (arc operon) provides a metabolic niche by transforming arginine into metabolic byproducts. We investigate the role of the arc operon in probiotic Escherichia coli Nissle 1917 on human gut community assembly and healt...
Early diagnosis of bloodstream infection (BSI) is crucial for informed antibiotic use. This study developed a machine learning approach for early BSI detection using a comprehensive dataset from Rigshospitalet, Denmark (2010-2020). The dataset includ...
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