AIMC Topic: Extracellular Matrix
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Effect of Oxidized LDL on Platelet Shape, Spreading, and Migration Investigated with Deep Learning Platelet Morphometry.
Cells
Oct 28, 2021
Platelets are functionally versatile blood cells involved in thrombosis, hemostasis, atherosclerosis, and immune response. Platelet interaction with the immediate microenvironment in blood, vasculature, and tissues alters platelet morphology. The qua...
Engineered Extracellular Matrices with Integrated Wireless Microactuators to Study Mechanobiology.
Advanced materials (Deerfield Beach, Fla.)
Aug 7, 2021
Mechanobiology explores how forces regulate cell behaviors and what molecular machinery are responsible for the sensing, transduction, and modulation of mechanical cues. To this end, probing of cells cultured on planar substrates has served as a prim...
Machine learning reveals mesenchymal breast carcinoma cell adaptation in response to matrix stiffness.
PLoS computational biology
Jul 23, 2021
Epithelial-mesenchymal transition (EMT) and its reverse process, mesenchymal-epithelial transition (MET), are believed to play key roles in facilitating the metastatic cascade. Metastatic lesions often exhibit a similar epithelial-like state to that ...
Humans
Machine Learning
Female
Tumor Microenvironment
Triple Negative Breast Neoplasms
Cell Proliferation
Antigens, CD
Cell Count
Biomarkers, Tumor
Cell Line, Tumor
Computational Biology
Cell Adhesion
Cell Shape
Adaptation, Physiological
Vimentin
Epithelial-Mesenchymal Transition
Neoplasm Metastasis
Cadherins
Extracellular Matrix
Models, Biological
Biophysical Phenomena
Super resolution microscopy and deep learning identify Zika virus reorganization of the endoplasmic reticulum.
Scientific reports
Dec 1, 2020
The endoplasmic reticulum (ER) is a complex subcellular organelle composed of diverse structures such as tubules, sheets and tubular matrices. Flaviviruses such as Zika virus (ZIKV) induce reorganization of ER membranes to facilitate viral replicatio...
Development of an Anisotropically Organized Brain dECM Hydrogel-Based 3D Neuronal Culture Platform for Recapitulating the Brain Microenvironment in Vivo.
ACS biomaterials science & engineering
Dec 31, 2019
To mimic the brain tissue microenvironment in vitro, the biological and structural properties of the utilized system must be similar to those of the native brain in the microenvironment in vivo. To promote the bioactive (biological) properties of mat...
Soft Ring-Shaped Cellu-Robots with Simultaneous Locomotion in Batches.
Advanced materials (Deerfield Beach, Fla.)
Nov 27, 2019
Untethered mini-robots can move single cells or aggregates to build complex constructs in confined spaces and may enable various biomedical applications such as regenerative repair in medicine and biosensing in bioengineering. However, a significant ...
Deep Learning for Drug Discovery and Cancer Research: Automated Analysis of Vascularization Images.
IEEE/ACM transactions on computational biology and bioinformatics
May 29, 2018
Likely drug candidates which are identified in traditional pre-clinical drug screens often fail in patient trials, increasing the societal burden of drug discovery. A major contributing factor to this phenomenon is the failure of traditional in vitro...
Phrase mining of textual data to analyze extracellular matrix protein patterns across cardiovascular disease.
American journal of physiology. Heart and circulatory physiology
May 18, 2018
Extracellular matrix (ECM) proteins have been shown to play important roles regulating multiple biological processes in an array of organ systems, including the cardiovascular system. Using a novel bioinformatics text-mining tool, we studied six cate...
Substrate stiffness affects neural network activity in an extracellular matrix proteins dependent manner.
Colloids and surfaces. B, Biointerfaces
Mar 27, 2018
Neuronal growth, differentiation, extension, branching and neural network activity are strongly influenced by the mechanical property of extracellular matrix (ECM). However, the mechanism by which substrate stiffness regulates a neural network activi...
Optimized Repopulation of Tendon Hydrogel: Synergistic Effects of Growth Factor Combinations and Adipose-Derived Stem Cells.
Hand (New York, N.Y.)
Mar 15, 2016
Tendon-derived extracellular matrix (ECM) hydrogel has been shown to augment tendon healing in vivo. We hypothesized that reseeding of the gel with adipose-derived stem cells (ASCs) could further assist repopulation of the gel and that combinations ...
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