AIMC Topic: Gastrointestinal Microbiome

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Exploiting the gut microbiota of aquatic animals as indicators of microplastic pollution using interpretable machine learning models.

Journal of hazardous materials
The response of aquatic animal gut microbiota to microplastics has been extensively studied and shows sensitivity, however, the potential of using gut microbiota as indicators for microplastic pollution has not yet been fully explored. To address thi...

Gut microbiota composition is related to anxiety and aggression scores in companion dogs.

Scientific reports
There is mounting evidence for a link between behaviour and the gut microbiome in animal and human health. However, the role of the gut microbiome in the development and severity of behavioural issues in companion dogs is not yet fully understood. He...

Multi-kingdom microbiota analysis reveals bacteria-viral interplay in IBS with depression and anxiety.

NPJ biofilms and microbiomes
Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder frequently accompanied by psychological symptoms. Bacterial microbiota plays a critical role in mediating local and systemic immunity, and alterations in these microbial communities...

Gut microbiome alterations and hepatic encephalopathy post-TIPS in liver cirrhosis patients.

Journal of translational medicine
BACKGROUND: The transjugular intrahepatic portosystemic shunt (TIPS), a crucial tool for treating complications related to portal hypertension in patients with liver cirrhosis, is often associated with an increased risk of postoperative complications...

Associations between weight gain, integrase inhibitors antiretroviral agents, and gut microbiome in people living with HIV: a cross-sectional study.

Scientific reports
Dolutegravir and bictegravir are second-generation HIV integrase strand transfer inhibitors (INSTIs) that were previously associated with abnormal weight gain. This monocentric cross-sectional study investigates associations between weight gain durin...

Targeted metabolomics reveals bioactive inflammatory mediators from gut into blood circulation in children with NAFLD.

NPJ biofilms and microbiomes
Altered gut metabolites are important for the inflammatory progression in children with NAFLD. Fecal and plasma samples were collected from 145 subjects including 53 non-alcoholic fatty liver (NAFL), 39 nonalcoholic steatohepatitis (NASH) and 53 obes...

Oral and Gut Dysbiosis in Migraine: Oral Microbial Signatures as Biomarkers of Migraine.

Neurology(R) neuroimmunology & neuroinflammation
BACKGROUND AND OBJECTIVES: Emerging evidence suggests that oral health conditions may exacerbate migraine, and saliva is a potential source of biomarkers for migraine. The 3-way interaction of the oral-gut-brain axis has been implicated in several ne...

Identification of novel biomarkers linked to M1 macrophage infiltration in the diagnosis of inflammatory bowel diseases.

International immunopharmacology
Inflammatory bowel disease (IBD) often lacks a definitive diagnostic standard, leading to diagnoses through exclusion. This study aimed to create a predictive model for IBD using bioinformatics and deep learning while identifying potential biomarkers...

Micronutrient supplementation influences the composition and diet-originating function of the gut microbiome in healthy adults.

Clinical nutrition (Edinburgh, Scotland)
BACKGROUND & AIMS: Studies in-vitro and in animals propose that vitamins and minerals can alter the human gut microbiome. Human trials replicating these findings are scarce or used micronutrient supplementation in supraphysiological doses. We explore...

Enzymatic carbon-fluorine bond cleavage by human gut microbes.

Proceedings of the National Academy of Sciences of the United States of America
Fluorinated compounds are used for agrochemical, pharmaceutical, and numerous industrial applications, resulting in global contamination. In many molecules, fluorine is incorporated to enhance the half-life and improve bioavailability. Fluorinated co...