AIMC Topic: Gastrointestinal Microbiome
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The dawn of the revolution that will allow us to precisely describe how microbiomes function.
Journal of proteomics
Mar 11, 2025
The community of microorganisms inhabiting a specific environment, such as the human gut - including bacteria, fungi, archaea, viruses, protozoa, and others - is known as the microbiota. A holobiont, in turn, refers to an integrated ecological unit w...
Machine-learning assisted discovery unveils novel interplay between gut microbiota and host metabolic disturbance in diabetic kidney disease.
Gut microbes
Mar 6, 2025
Diabetic kidney disease (DKD) is a serious healthcare dilemma. Nonetheless, the interplay between the functional capacity of gut microbiota and their host remains elusive for DKD. This study aims to elucidate the functional capability of gut microbio...
Altered Gut Microbiome Composition and Function in Individuals with Complex Regional Pain Syndrome.
Anesthesiology
Mar 5, 2025
BACKGROUND: Complex regional pain syndrome is a chronic pain syndrome typically affecting a limb. It is characterized by severe spontaneous and evoked pain, along with vasomotor, autonomic, and motor signs and symptoms. Although dysregulation in seve...
Mathematical Modeling and Artificial Intelligence to Explore Connections Between Glaucoma and the Gut Microbiome.
Medicina (Kaunas, Lithuania)
Feb 14, 2025
Glaucoma is a major cause of irreversible blindness, with primary open-angle glaucoma (POAG) being the most prevalent form. While elevated intraocular pressure (IOP) is a well-known risk factor for POAG, emerging evidence suggests that the human gut...
Probing the eukaryotic microbes of ruminants with a deep-learning classifier and comprehensive protein databases.
Genome research
Feb 14, 2025
Metagenomics, particularly genome-resolved metagenomics, have significantly deepened our understanding of microbes, illuminating their taxonomic and functional diversity and roles in ecology, physiology, and evolution. However, eukaryotic populations...
Intestinal Microbiome Modulation of Therapeutic Efficacy of Cancer Immunotherapy.
Gastroenterology clinics of North America
Jan 24, 2025
Bacteria are associated with certain cancers and may induce genetic instability and cancer progression. The gut microbiome modulates the response to cancer therapy. Training machine learning models with response associated taxa or bacterial genes pre...
Predicting metabolite response to dietary intervention using deep learning.
Nature communications
Jan 18, 2025
Due to highly personalized biological and lifestyle characteristics, different individuals may have different metabolite responses to specific foods and nutrients. In particular, the gut microbiota, a collection of trillions of microorganisms living ...
Machine Learning-Assisted High-Throughput Screening of Nanozymes for Ulcerative Colitis.
Advanced materials (Deerfield Beach, Fla.)
Jan 12, 2025
Ulcerative colitis (UC) is a chronic gastrointestinal inflammatory disorder with rising prevalence. Due to the recurrent and difficult-to-treat nature of UC symptoms, current pharmacological treatments fail to meet patients' expectations. This study ...
SProtFP: a machine learning-based method for functional classification of small ORFs in prokaryotes.
NAR genomics and bioinformatics
Jan 7, 2025
Small proteins (≤100 amino acids) play important roles across all life forms, ranging from unicellular bacteria to higher organisms. In this study, we have developed SProtFP which is a machine learning-based method for functional annotation of prokar...
MO-GCN: A multi-omics graph convolutional network for discriminative analysis of schizophrenia.
Brain research bulletin
Jan 7, 2025
The methodology of machine learning with multi-omics data has been widely adopted in the discriminative analyses of schizophrenia, but most of these studies ignored the cooperative interactions and topological attributes of multi-omics networks. In t...
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