AIMC Topic: Gene Regulatory Networks

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Exploration of autophagy-associated genes and potential molecular mechanisms in type 1 diabetes and osteoporosis.

Scientific reports
The co-occurrence of osteoporosis (OP) and type 1 diabetes mellitus (T1DM) represents a clinically significant comorbidity pattern, characterized by skeletal fragility and insulin deficiency. While epidemiological links exist, their shared molecular ...

Screening, identification, and experimental validation of SUMOylation biomarkers in Parkinson's disease.

Hereditas
BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative disorder. The role of protein post-translational modifications (PTMs), especially small ubiquitin-like modifier (SUMO) conjugation (SUMOylation), in PD pathogenesis remains unclear. T...

Identification and validation of hub genes related to neutrophil extracellular traps-mediated cell damage and immune recruitment during abdominal aortic aneurysm.

Scientific reports
Previous research has shown that the formation of Neutrophil Extracellular Traps (NETs), mediated by neutrophils, leads to an increase in inflammatory cell response and cellular tissue damage during Abdominal Aortic Aneurysm (AAA). Building on this f...

Network-based approach identifies key genes associated with tumor heterogeneity in HPV positive and negative head and neck cancer patients.

Scientific reports
Head and Neck Squamous Cell Carcinoma (HNSCC) is the seventh most prevalent cancer worldwide and is classified as human papillomavirus (HPV) positive or negative. Substantial heterogeneity has been observed in the two groups, posing a significant cli...

Identification and experimental validation of mitochondrial and endoplasmic reticulum stress related gene in diabetic nephropathy.

Scientific reports
Diabetic nephropathy (DN) is a kidney disease. Mitochondrial and endoplasmic reticulum stress (ERS) significantly contribute to diabetic nephropathy (DN), although the precise mechanisms involved have not yet been fully understood. The objective of t...

Identifying ferroptosis-related genes in lung adenocarcinoma using random walk with restart in the PPI network.

Scientific reports
Lung adenocarcinoma (LUAD), the most common non-small cell lung cancer subtype, often presents with subtle early symptoms leading to delayed diagnosis. Ferroptosis, a cell death process associated with iron metabolism dysregulation, has been linked t...

In-depth bioinformatics analysis uncovers the crosstalk genes and immune interactions among diagnostic markers linked to natural killer cells in patients with cirrhosis and sepsis.

Clinical and experimental medicine
Patients with cirrhosis face an elevated risk of developing sepsis, leading to an escalating mortality rate. This study focuses on the link between natural killer (NK) cells, cirrhosis, and sepsis. Our goal is to identify NK cell-related genes that c...

Bioinformatics analysis of Rho-signal transduction genes in postmenopausal osteoporosis and periodontitis.

Scientific reports
Postmenopausal osteoporosis (PMOP) increases the risk of periodontitis (PD), yet the shared mechanisms remain unclear. Rho-signal transduction genes may play a role due to their involvement in bone remodeling. This study aimed to explore Rho-related ...

Identification of DNA damage response and crotonylation-related biomarkers for lung adenocarcinoma via machine learning and WGCNA.

Clinical and experimental medicine
DNA damage response (DDR) and crotonylation occur frequently in lung adenocarcinoma (LUAD), but their relationship is yet to be elucidated. RNA sequencing data from LUAD patients in GSE27262 and GSE140797 datasets were obtained. DDR-crotonylation-rel...

Interpretable graph Kolmogorov-Arnold networks for multi-cancer classification and biomarker identification using multi-omics data.

Scientific reports
The integration of heterogeneous multi-omics datasets at a systems level remains a central challenge for developing analytical and computational models in precision cancer diagnostics. This paper introduces Multi-Omics Graph Kolmogorov-Arnold Network...