AIMC Topic: Genome-Wide Association Study

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Network-Based Identification and Prioritization of Key Regulators of Coronary Artery Disease Loci.

Arteriosclerosis, thrombosis, and vascular biology Mar 10, 2016
OBJECTIVE: Recent genome-wide association studies of coronary artery disease (CAD) have revealed 58 genome-wide significant and 148 suggestive genetic loci. However, the molecular mechanisms through which they contribute to CAD and the clinical impli...
Mice Genomics Genetic Predisposition to Disease Computational Biology Genome-Wide Association Study Protein Interaction Maps Gene Regulatory Networks STAT3 Transcription Factor Genetic Loci Gene Expression Regulation Lumican Signal Transduction Databases, Genetic Bayes Theorem Coronary Artery Disease Humans Neural Networks, Computer Phenotype Computer Simulation Animals Gene Expression Profiling Case-Control Studies
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Learning Predictive Interactions Using Information Gain and Bayesian Network Scoring.

PloS one Dec 1, 2015
BACKGROUND: The problems of correlation and classification are long-standing in the fields of statistics and machine learning, and techniques have been developed to address these problems. We are now in the era of high-dimensional data, which is data...
Polymorphism, Single Nucleotide Machine Learning Computational Biology Algorithms Bayes Theorem Genome-Wide Association Study
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Powerful Tests for Multi-Marker Association Analysis Using Ensemble Learning.

PloS one Nov 30, 2015
Multi-marker approaches have received a lot of attention recently in genome wide association studies and can enhance power to detect new associations under certain conditions. Gene-, gene-set- and pathway-based association tests are increasingly bein...
Machine Learning Genome-Wide Association Study Humans Phenotype Polymorphism, Single Nucleotide Asthma Genetic Markers
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Genome-Wide Locations of Potential Epimutations Associated with Environmentally Induced Epigenetic Transgenerational Inheritance of Disease Using a Sequential Machine Learning Prediction Approach.

PloS one Nov 16, 2015
Environmentally induced epigenetic transgenerational inheritance of disease and phenotypic variation involves germline transmitted epimutations. The primary epimutations identified involve altered differential DNA methylation regions (DMRs). Differen...
Sertoli Cells CpG Islands Chromosomes Reproducibility of Results DDT Male Methoxychlor Genome-Wide Association Study Spermatozoa Humans DNA Methylation Genetic Predisposition to Disease Computational Biology Environmental Exposure Machine Learning Epigenesis, Genetic Granulosa Cells Cluster Analysis Phenotype Databases, Genetic Bayes Theorem Female Sequence Analysis, DNA Mutation
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Genome-Wide Detection and Analysis of Multifunctional Genes.

PLoS computational biology Oct 5, 2015
Many genes can play a role in multiple biological processes or molecular functions. Identifying multifunctional genes at the genome-wide level and studying their properties can shed light upon the complexity of molecular events that underpin cellular...
Proteome Natural Language Processing Data Mining Multigene Family Humans Animals Genome-Wide Association Study Drosophila melanogaster Drosophila Proteins Genome Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Species Specificity Chromosome Mapping
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Sparse Markov chain-based semi-supervised multi-instance multi-label method for protein function prediction.

Journal of bioinformatics and computational biology Sep 16, 2015
Automated assignment of protein function has received considerable attention in recent years for genome-wide study. With the rapid accumulation of genome sequencing data produced by high-throughput experimental techniques, the process of manually pre...
Computational Biology Proteins Databases, Protein Supervised Machine Learning Algorithms Animals Genome-Wide Association Study Markov Chains
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Knowledge-based analysis of genetic associations of rheumatoid arthritis to inform studies searching for pleiotropic genes: a literature review and network analysis.

Arthritis research & therapy Aug 8, 2015
INTRODUCTION: Pleiotropy describes the genetic effect of a single gene on multiple phenotypic traits. Gene variants directly affect the normal processes of a series of physiological and biochemical reactions, and therefore cause a variety of diseases...
Genome-Wide Association Study Gene Regulatory Networks Arthritis, Rheumatoid Genetic Predisposition to Disease Polymorphism, Single Nucleotide Knowledge Bases Genetic Pleiotropy Humans
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A Comparative Study on Multifactor Dimensionality Reduction Methods for Detecting Gene-Gene Interactions with the Survival Phenotype.

BioMed research international Aug 3, 2015
Genome-wide association studies (GWAS) have extensively analyzed single SNP effects on a wide variety of common and complex diseases and found many genetic variants associated with diseases. However, there is still a large portion of the genetic vari...
Humans Algorithms Phenotype Computer Simulation Genome-Wide Association Study Genetic Predisposition to Disease Multifactor Dimensionality Reduction Polymorphism, Single Nucleotide Genotype Epistasis, Genetic
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Model-Based Multifactor Dimensionality Reduction for Rare Variant Association Analysis.

Human heredity Jul 28, 2015
Genome-wide association studies have revealed a vast amount of common loci associated to human complex diseases. Still, a large proportion of heritability remains unexplained. The extent to which rare genetic variants (RVs) are able to explain a rele...
Genetic Variation Humans Genome-Wide Association Study Multifactor Dimensionality Reduction Models, Genetic Chromosomes, Human, Pair 4
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Identification of active transcriptional regulatory elements from GRO-seq data.

Nature methods Mar 23, 2015
Modifications to the global run-on and sequencing (GRO-seq) protocol that enrich for 5'-capped RNAs can be used to reveal active transcriptional regulatory elements (TREs) with high accuracy. Here, we introduce discriminative regulatory-element detec...
Histones Quantitative Trait Loci Regulatory Elements, Transcriptional Cell Line Gene Expression Regulation K562 Cells Humans Artificial Intelligence Software Genome-Wide Association Study Polymorphism, Single Nucleotide
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