AIMC Topic: Glucocorticoids

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Identification of glucocorticoid-related genes in systemic lupus erythematosus using bioinformatics analysis and machine learning.

PloS one Mar 25, 2025
BACKGROUND: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that has significant impacts on patients' quality of life and poses a substantial economic burden on society.
Humans Machine Learning Glucocorticoids Molecular Docking Simulation Gene Expression Profiling Gene Regulatory Networks Transcriptome Computational Biology Case-Control Studies Cluster Analysis Lupus Erythematosus, Systemic
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Clinical characteristics of adrenal crisis in 371 adult patients with glucocorticoid-induced adrenal insufficiency.

Frontiers in endocrinology Dec 17, 2024
BACKGROUND: Glucocorticoid-induced adrenal insufficiency (GIAI) is a hypothalamic-pituitary-adrenal (HPA) axis dysfunction caused by long-term use of exogenous steroids. Adrenal crisis (AC) is an acute complication of GIAI and one of the reasons for ...
Female Humans Male Prognosis Risk Factors Middle Aged Retrospective Studies Aged Glucocorticoids Adult Adrenal Insufficiency
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[Adrenal insufficiency as part of X-linked adrenoleukodystrophy].

Problemy endokrinologii Dec 5, 2023
BACKGROUND:  X-linked adrenoleukodystrophy (X-ALD) is a severe neurodegenerative metabolic disease with a frequency 1:17,000 in newborn boys. Being a major part of X-ALD with an incidence of 70-80% of patients, adrenal insufficiency (AI) is a life-th...
Adrenoleukodystrophy Humans Mineralocorticoids Retrospective Studies Male Adolescent Glucocorticoids Child, Preschool Child Adrenal Insufficiency
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Screening of Potential Biomarkers in the Peripheral Serum for Steroid-Induced Osteonecrosis of the Femoral Head Based on WGCNA and Machine Learning Algorithms.

Disease markers Feb 10, 2022
BACKGROUND: Steroid-induced osteonecrosis of the femoral head (SONFH) has produced a substantial burden of medical and social experience. However, the current diagnosis is still limited. Thus, this study is aimed at identifying potential biomarkers i...
Femur Head Necrosis Algorithms Biomarkers Glucocorticoids Gene Regulatory Networks Humans Machine Learning
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Evaluation of Glucocorticoid Therapy in Asthma Children with Small Airway Obstruction Based on CT Features of Deep Learning.

Computational and mathematical methods in medicine Dec 21, 2021
This study was aimed at exploring the treatment of asthma children with small airway obstruction in CT imaging features of deep learning and glucocorticoid. A total of 145 patients meeting the requirements in hospital were included in this study, and...
Computational Biology Airway Obstruction Fractional Exhaled Nitric Oxide Testing Deep Learning Adolescent Child, Preschool Child Humans Algorithms Tomography, X-Ray Computed Female Asthma Male Glucocorticoids Lung
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Deep Learning Algorithms-Based CT Images in Glucocorticoid Therapy in Asthma Children with Small Airway Obstruction.

Journal of healthcare engineering Oct 21, 2021
CT image information data under deep learning algorithms was adopted to evaluate small airway function and analyze the clinical efficacy of different glucocorticoid administration ways in asthmatic children with small airway obstruction. The Res-NET ...
Humans Deep Learning Child Airway Obstruction Algorithms Tomography, X-Ray Computed Asthma Glucocorticoids
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Predicting hearing recovery following treatment of idiopathic sudden sensorineural hearing loss with machine learning models.

American journal of otolaryngology Jan 4, 2021
PURPOSE: Idiopathic sudden sensorineural hearing loss (ISSHL) is an emergency otological disease, and its definite prognostic factors remain unclear. This study applied machine learning methods to develop a new ISSHL prognosis prediction model.
Humans Logistic Models Recovery of Function Hearing Hearing Loss, Sensorineural Hearing Loss, Sudden Adult Injections, Intralesional Machine Learning Male Prognosis Middle Aged Retrospective Studies Glucocorticoids Female
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Assessment of Machine Learning to Estimate the Individual Treatment Effect of Corticosteroids in Septic Shock.

JAMA network open Dec 1, 2020
IMPORTANCE: The survival benefit of corticosteroids in septic shock remains uncertain.
Critical Care Risk Adjustment Organ Dysfunction Scores Fludrocortisone Shock, Septic Machine Learning Randomized Controlled Trials as Topic Female Hydrocortisone Humans Prognosis Aged Male Intensive Care Units Glucocorticoids Clinical Decision-Making
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Circulating Neutrophil Extracellular Traps Signature for Identifying Organ Involvement and Response to Glucocorticoid in Adult-Onset Still's Disease: A Machine Learning Study.

Frontiers in immunology Nov 9, 2020
Adult-onset Still's disease (AOSD) is an autoinflammatory disease with multisystem involvement. Early identification of patients with severe complications and those refractory to glucocorticoid is crucial to improve therapeutic strategy in AOSD. Exag...
Cell-Free Nucleic Acids Humans Cytokines Still's Disease, Adult-Onset Male Treatment Outcome Prognosis Extracellular Traps Middle Aged Female Support Vector Machine Glucocorticoids Young Adult Case-Control Studies Adult
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Effect of congenital adrenal hyperplasia treated by glucocorticoids on plasma metabolome: a machine-learning-based analysis.

Scientific reports Jun 1, 2020
BACKGROUND: Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency leads to impaired cortisol biosynthesis. Treatment includes glucocorticoid supplementation. We studied the specific metabolomics signatures in CAH patients using two di...
Female Young Adult Adult Male Glucocorticoids Case-Control Studies ROC Curve Metabolomics Humans Machine Learning Adrenal Hyperplasia, Congenital Pyrimidines Indoleamine-Pyrrole 2,3,-Dioxygenase Metabolome Area Under Curve Hydrocortisone Purines
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