AIMC Topic: Hepatitis B, Chronic
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Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of HBeAg-positive chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial.
The lancet. Gastroenterology & hepatology
Sep 22, 2016
BACKGROUND: Tenofovir alafenamide is a novel prodrug formulated to deliver the active metabolite to target cells more efficiently than tenofovir disoproxil fumarate at a lower dose, thereby reducing systemic exposure. In patients with HIV, tenofovir ...
Intrahepatic bile duct adenoma in a patient with chronic hepatitis B accompanied by elevation of alpha-fetoprotein.
Clinical and molecular hepatology
Dec 24, 2015
A 51-year-old male patient with chronic hepatitis B was referred to our hospital due to a 1-cm liver nodule on ultrasonography. Alpha-fetoprotein (AFP) was slightly elevated. The nodule showed prolonged enhancement on dynamic liver magnetic resonance...
Serological proteomic characterization for monitoring liver fibrosis regression in chronic hepatitis B patients on treatment.
Nature communications
Aug 19, 2025
Longitudinal serological proteomic dynamics during antiviral therapy (AVT) in chronic hepatitis B (CHB) patients with liver fibrosis remain poorly characterized. Here, using four-dimensional data-independent acquisition mass spectrometry (4D-DIA-MS),...
Paternally Expressed Gene 10 Promoter Methylation Level as a Predictor of HBeAg Seroconversion in Chronic Hepatitis B Patients.
Journal of medical virology
Aug 1, 2025
The management of chronic hepatitis B (CHB) encounters challenges like suboptimal antiviral response and the lack of predictive biomarkers. In this study, the role of paternally expressed gene 10 (PEG10) in hepatitis B e antigen (HBeAg) seroconversio...
Enhancing HF-DL Model Validation for Liver Fibrosis Staging Through Sample Optimisation and Technical Integration.
Liver international : official journal of the International Association for the Study of the Liver
Aug 1, 2025
We read with great interest the article by Zhang et al. The study demonstrates that the deep learning model based on high-frequency ultrasound images significantly outperforms the low-frequency ultrasound model, FIB-4, APRI, and shear wave elastograp...
A Deep Learning Model Based on High-Frequency Ultrasound Images for Classification of Different Stages of Liver Fibrosis.
Liver international : official journal of the International Association for the Study of the Liver
Jul 1, 2025
BACKGROUND AND AIMS: To develop a deep learning model based on high-frequency ultrasound images to classify different stages of liver fibrosis in chronic hepatitis B patients.
Machine learning algorithms reveal gut microbiota signatures associated with chronic hepatitis B-related hepatic fibrosis.
World journal of gastroenterology
Apr 28, 2025
BACKGROUND: Hepatic fibrosis (HF) represents a pivotal stage in the progression and potential reversal of cirrhosis, underscoring the importance of early identification and therapeutic intervention to modulate disease trajectory.
Application of Interpretable Machine Learning Models to Predict the Risk Factors of HBV-Related Liver Cirrhosis in CHB Patients Based on Routine Clinical Data: A Retrospective Cohort Study.
Journal of medical virology
Mar 1, 2025
Chronic hepatitis B (CHB) infection represents a significant global public health issue, often leading to hepatitis B virus (HBV)-related liver cirrhosis (HBV-LC) with poor prognoses. Early identification of HBV-LC risk is essential for timely interv...
Review on article of preoperative prediction in chronic hepatitis B virus patients using spectral computed tomography and machine learning.
World journal of gastroenterology
Oct 14, 2024
This letter comments on the article that developed and tested a machine learning model that predicts lymphovascular invasion/perineural invasion status by combining clinical indications and spectral computed tomography characteristics accurately. We ...
[A study of the clinical curative effect of nucleos(t)ide analogues treated to pegylated interferon-α add-on therapy in patients with chronic hepatitis B].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
Dec 20, 2023
To investigate the hepatitis B surface antigen (HBsAg) clearance condition and its predictive factors after treatment with nucleos(t)ide analogues to pegylated interferon-α add-on therapy in patients with chronic hepatitis B. Patients with chronic ...
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