The food industry is continually evolving, driven by the demand for innovative processing technologies capable of preserving the nutritional and functional properties while ensuring food safety and quality. Traditional thermal processing frequently r...
Univariate and multivariate Cox analyses revealed a correlation between diabetes and the prognosis of gastric cancer patients (p < 0.05). Using bioinformatics, Serine/threonine-protein kinase pim-1 (PIM1) was identified as the core target gene of tri...
Mitochondria play essential roles in cellular energy metabolism and biological processes, with their dysfunction implicated in various diseases. Mitochondria-targeted fluorescent probes have thus been developed to sensitively detect metabolites and m...
Machine learning (ML) modeling on mass spectrometry (MS)-based shotgun data facilitates feature selection and disease modeling. However, batch-specific models often struggle with limited transferability and generalizability, necessitating data integr...
Journal of chemical theory and computation
Nov 25, 2025
Identifying collective variables (CVs) that are both discriminative and interpretable remains a central challenge for enhanced sampling and mechanistic analysis of biomolecular systems. We present (), a supervised machine learning-based CV discovery...
Proceedings of the National Academy of Sciences of the United States of America
Nov 25, 2025
Protein misfolding plays a central role in diseases such as Alzheimer's disease, Parkinson's disease, type 2 diabetes, and transthyretin amyloidosis (ATTR), often driven by specific aggregation-prone segments such as A and A of amyloid-42 (A42), -Syn...
UNLABELLED: This article aims to evaluate the quality of responses provided by AI systems ChatGPT-4o and Gemini 1.5 to frequently asked patient questions regarding pectus deformity.
BACKGROUND: The brain-gut system, which involves bidirectional communication between the central nervous system and the gut, plays a central role in stress responses. Its dysregulation is implicated in irritable bowel syndrome (IBS), a stress-sensiti...
BACKGROUND: Subjective well-being has become a core indicator for measuring social progress and policy effectiveness. However, the "Easterlin Paradox" remains prevalent, and this paradox refers to the disconnect between economic growth and improvemen...
BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disorder with complex underlying mechanisms. PANoptosis, a newly defined form of programmed cell death that integrates pyroptosis, apoptosis, and necroptosis, may play a crucial ...
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