Drug-target affinity (DTA) prediction is a critical aspect of drug discovery. The meaningful representation of drugs and targets is crucial for accurate prediction. Using 1D string-based representations for drugs and targets is a common approach that...
International journal of molecular sciences
Mar 12, 2025
Chronic myeloid leukemia is a clonal hematologic disease characterized by the presence of the Philadelphia chromosome and the BCR::ABL1 fusion protein. Integrating different molecular, genetic, clinical, and laboratory data would improve the diagnost...
Cancer imaging : the official publication of the International Cancer Imaging Society
Mar 12, 2025
PURPOSE: This study aimed to select robust features against lung motion in a phantom study and use them as input to feature selection algorithms and machine learning classifiers in a clinical study to predict the lymphovascular invasion (LVI) of non-...
BACKGROUND: Capillariid nematode eggs have been reported in archaeological material in both the New and the Old World, mainly in Europe and South America. They have been found in various types of samples, as coprolites, sediments from latrines, pits,...
Cancer imaging : the official publication of the International Cancer Imaging Society
Mar 12, 2025
BACKGROUND: Programmed death ligand 1 (PD-L1) expression status, closely related to immunotherapy outcomes, is a reliable biomarker for screening patients who may benefit from immunotherapy. Here, we developed and validated an interpretable machine l...
BACKGROUND: Vaccine hesitancy, the delay in acceptance or reluctance to vaccinate, ranks among the top threats to global health. Identifying modifiable factors contributing to vaccine hesitancy is crucial for developing targeted interventions to incr...
OBJECTIVE: Predicting healthcare demand is essential for effective resource allocation and planning. This study applies Andersen's Behavioral Model of Health Services Use, focusing on predisposing, enabling, and need factors, using data from the 2022...
BACKGROUND: Dengue fever is a mosquito-borne viral disease that poses significant health risks and socioeconomic challenges in Brazil, necessitating accurate forecasting across its 27 federal states. With the country's diverse climate and geographica...
BACKGROUND: Early and accurate identification of epidermal growth factor receptor (EGFR) mutation status in non-small cell lung cancer (NSCLC) patients with brain metastases is critical for guiding targeted therapy. This study aimed to develop a deep...
The evolution experienced by global society, in the post-COVID 19 era, is marked by the quite obligatory use of digital media in many sectors, as is the case for the health sector. Quite frequently, both patients and health professionals use social m...
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