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Streamlining medical software development with CARE lifecycle and CARE agent: an AI-driven technology readiness level assessment tool.
BMC medical informatics and decision making
Jul 8, 2025
BACKGROUND: Developing medical software requires navigating complex regulatory, ethical, and operational challenges. A comprehensive framework that supports both technical maturity and clinical safety is essential for effective artificial intelligenc...
Comparison of 2D, 2.5D, and 3D segmentation networks for mandibular canals in CBCT images: a study on public and external datasets.
BMC oral health
Jul 8, 2025
The purpose of this study was to compare the performances of 2D, 2.5D, and 3D CNN-based segmentation networks, along with a 3D vision transformer-based segmentation network, for segmenting mandibular canals (MCs) on the public and external CBCT datas...
A systematic multimodal assessment of AI machine translation tools for enhancing access to critical care education internationally.
BMC medical education
Jul 8, 2025
BACKGROUND: Language barriers pose a significant barrier to expanding access to critical care education worldwide. Machine translation (MT) offers significant promise to increase accessibility to critical care content, and has rapidly evolved using n...
Protocol for the REBOUND study: a cohort study to uncover fundamental mechanisms of accelerated ageing and impaired resilience following cancer surgery and treatment.
BMC geriatrics
Jul 8, 2025
BACKGROUND: Ageing is a heterogeneous process, which is associated with heterogeneous resilience in older people. Cancer surgery and treatment may be associated with accelerated ageing in some older people; studying this process will improve understa...
Machine learning-based QSAR and structure-based virtual screening guided discovery of novel mIDH1 inhibitors from natural products.
Journal of computer-aided molecular design
Jul 8, 2025
Mutations in isocitrate dehydrogenase 1 (IDH1) have been widely observed in various tumors, such as gliomas and acute myeloid leukemia, and therefore has become one of the current research focal points. Therefore, it is crucial to find inhibitors tha...
The application and discovery of animal models in enterovirus research.
Archives of virology
Jul 8, 2025
Enterovirus infection remains a significant global public health challenge, causing severe diseases such as hand, foot, and mouth disease (HFMD) and meningitis. Given the current lack of effective broad-spectrum antiviral therapies, it is important t...
Interpretability-guided RNA N-methyladenosine modification site prediction with invertible neural networks.
Communications biology
Jul 8, 2025
As one of the most common and abundant post-transcriptional modifications, N-methyladenosine (mA) has been extensively studied for its essential regulatory role in gene expression and cell functions. The location of mA RNA modification sites, however...
Explainable deep learning approaches for high precision early melanoma detection using dermoscopic images.
Scientific reports
Jul 8, 2025
Detecting skin melanoma in the early stage using dermoscopic images presents a complex challenge due to the inherent variability in images. Utilizing dermatology datasets, the study aimed to develop Automated Diagnostic Systems for early skin cancer ...
Machine learning assisted adjustment boosts efficiency of exact inference in randomized controlled trials.
Scientific reports
Jul 8, 2025
In this work, we proposed a novel inferential procedure assisted by machine learning based adjustment for randomized control trials. The method was developed under the Rosenbaum's framework of exact tests in randomized experiments with covariate adju...
Metabolic alterations driven by LDHA in CD8 + T cells promote immune evasion and therapy resistance in NSCLC.
Scientific reports
Jul 8, 2025
Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths worldwide. Despite advancements in treatment, prognosis for patients with advanced stages remains poor. Metabolic reprogramming in the tumor microenvironment, particularly...
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