This tutorial offers a step-by-step guide for analytical chemists to train machine learning models for MS-based metabolomics. It covers data preparation, feature engineering, model selection, evaluation, and interpretation, along with real-world exam...
Precise subcellular localization is crucial for the design of molecular probes and targeted therapeutics, yet selectively distinguishing organelles with similar physicochemical properties, such as lipid droplets, mitochondria, and the cell membrane, ...
Proceedings of the National Academy of Sciences of the United States of America
Oct 17, 2025
Speech comprehension involves transforming an acoustic waveform into meaning. To do so, the human brain generates a hierarchy of features that converts the sensory input into increasingly abstract language properties. However, little is known about h...
BACKGROUND: Rheumatoid arthritis (RA), particularly seronegative disease, is difficult to diagnose early, which can delay treatment initiation. This study aims to develop a binary DNA methylation (DNAm)-based algorithm to diagnose RA.
BACKGROUND: Obesity has emerged as a major global public health challenge and poses a significant threat to human health. Despite extensive research, the mechanisms underlying its pathological progression remain elusive.
BACKGROUND: Artificial intelligence (AI) offers significant potential to drive advancements in healthcare; however, the development and implementation of AI models present complex ethical, legal, social, and technical challenges, as data practices of...
OBJECTIVE: The integration of artificial intelligence (AI) into CAD/CAM workflows has revolutionized dental prosthetics manufacturing, yet its morphological trueness compared to manual design remains underexplored.
INTRODUCTION: Knee osteoarthritis (KOA) is a prevalent degenerative joint disorder affecting a significant portion of the elderly population. Despite the availability of various non-surgical and pharmacological treatments, their effectiveness is ofte...
BACKGROUND: The advancement of digital technologies has brought transformative changes across the healthcare sector, and nursing is no exception. However, existing research has largely overlooked the ethical challenges nursing students face in real-w...
BACKGROUND: It remains unclear whether certain individuals with type 2 diabetes (T2D) derive greater cardiovascular benefit from GLP-1 receptor agonists (GLP-1RAs). Here, we integrate individual-level data from cardiovascular outcome trials (CVOTs) a...
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