BACKGROUND: Metabolic syndrome (MetS) and sarcopenia are major global public health problems, and their coexistence significantly increases the risk of death. In recent years, this trend has become increasingly prominent in younger populations, posin...
Capturing the dynamic changes in patients' internal states as they approach death due to fatal diseases remains a major challenge in understanding individual pathologies and improving end-of-life care. However, existing methods primarily focus on spe...
BACKGROUND: Disulfidptosis, a novel cellular death manner, has yet to be fully explored within the context of pulmonary arterial hypertension (PAH). This study aims to identify genes implicated in PAH that are involved in disulfidptosis.
BACKGROUND: Financial hardship (including financial stress, financial strain, asset depletion, and financial toxicity) is a highly relevant construct among the 6.9 million people living with Alzheimer's disease and related dementias (ADRD) in the Uni...
Marine bioactive peptides (MBPs) are short-chain amino acid polymers derived from marine sources that possess specific physiological activities. Owing to their unique origins and structural diversity, MBPs have attracted considerable research interes...
Sweat, a biofluid rich in various biomarkers, offers significant potential for non-invasive health monitoring and disease screening. Colorimetric detection is well-suited for multi-analyte quantification and point-of-care testing in sweat analysis, w...
European journal of medicinal chemistry
Sep 8, 2025
Accurate prediction of drug-target binding affinity is crucial for efficient drug discovery and design, enabling researchers to better understand molecular interactions and accelerate the identification of promising drug candidates. Despite recent ad...
Computer assisted surgery (Abingdon, England)
Sep 8, 2025
To develop a DeepSurv model for predicting survival in pancreatic adenocarcinoma patients, evaluating the benefit of surgical versus non-surgical treatment across different stages, including stage IV subcategories. Clinical data were extracted from t...
Journal of chemical theory and computation
Sep 8, 2025
RNA plays a pivotal role in biological processes such as gene expression regulation and protein synthesis. Targeting RNA with small molecules offers a novel therapeutic strategy for various diseases by directly modulating these processes. However, th...
While the cancer genome is well-studied, the nongenetic exposome of cancer remains elusive, particularly for regionally prevalent cancers with poor prognosis. Here, by employing a combined knowledge- and data-driven strategy, we profile the chemical ...
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