AIMC Topic: Humans

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Quantification of spp. using fluorescence and SERS spectroscopy for bloodstream infection diagnosis.

Journal of materials chemistry. B
Bloodstream infections caused by spp. are among the leading hospital-acquired infections, but their diagnosis remains slow and challenging with conventional culture-based methods, which often require days to deliver results. This study aimed to deve...

Pluronic nanoparticle-modified modular bacterial robots for therapy of tumors and inflammatory bowel disease.

Journal of materials chemistry. B
Bacterial-mediated drug delivery has emerged as a promising strategy for disease treatment, leveraging bacteria's innate ability to penetrate biological barriers and target diseased tissues. However, existing bacteria-nanoparticle hybrid systems ofte...

Incorporating and quantifying deformable image registration uncertainties in dose accumulation: a feasibility study on the benefit of online adaptive therapy.

Physics in medicine and biology
. Accurate dose accumulation relies on deformable image registration (DIR) to track dose across multiple images. However, DIR introduces uncertainties that can impact cumulative dose distributions. In this study, we present a probabilistic framework ...

mRNA-LNP vaccines: rational design, delivery optimization, and clinical translation.

Journal of materials chemistry. B
Messenger RNA (mRNA) vaccines face core challenges including low-delivery efficiency and immunogenicity, limiting their wide-ranging applications in infectious disease prevention and cancer therapy. Lipid nanoparticles (LNPs), the most clinically val...

Continuous Physiologic Markers of Heart Rate Variability Derived From Bedside Electrocardiogram Precede Onset of Acute Respiratory Distress Syndrome: A Physiologic Modeling Study.

Critical care explorations
OBJECTIVE: Acute respiratory distress syndrome (ARDS) is estimated to be prevalent in 10% of ICU patients and results in high mortality rates of up to 45%. The recognition of ARDS can be complex and is often delayed or missed entirely. Recognition of...

Temporal social network modeling of mobile connectivity data with graph neural networks.

PloS one
Graph neural networks (GNNs) have emerged as a state-of-the-art data-driven tool for modeling connectivity data of graph-structured complex networks and integrating information of their nodes and edges in space and time. However, as of yet, the analy...

Modulatory feedback determines attentional object segmentation in a model of the ventral stream.

PloS one
Studies in neuroscience inspired progress in the design of artificial neural networks (ANNs), and, vice versa, ANNs provide new insights into the functioning of brain circuits. So far, the focus has been on how ANNs can help to explain the tuning of ...

Data-driven prediction of future purchase behavior in cross-border e-commerce using sequence modeling with PSO-tuned LSTM.

PloS one
With the rapid advancement of cross-border e-commerce, accurately predicting user purchase behavior has emerged as a critical challenge for enhancing platform operational efficiency and user experience. This study proposes a hybrid deep learning fram...

Explainable AI for sign language recognition models: Integrating Grad-Cam LIME and Integrated Gradients.

PloS one
Sign language recognition is crucial in bridging the communication gaps between hearing and deaf communities. In this study, we build on an existing sign language classification model based on the VGG19 architecture, enhancing its robustness through ...

Development of machine learning models for prediction of current and future dementia.

PloS one
Dementia is among the most distressing and burdensome health challenges in aging populations. Treatment efficacy is limited; however, early diagnosis can delay or prevent disease progression. Previous machine learning-based prediction models have lim...