Humans

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Efficacy and safety of lebrikizumab in adult patients with mild-to-moderate asthma not receiving inhaled corticosteroids.

Respiratory medicine Dec 13, 2017
BACKGROUND: Asthma is a heterogeneous and complex disease in both its clinical course and response to treatment. IL-13 is central to Type 2 inflammation and contributes to many features of asthma. In a previous Phase 2 study, lebrikizumab, an anti-IL...
Treatment Failure Quinolines Administration, Inhalation Anti-Asthmatic Agents Forced Expiratory Volume Asthma Acetates Male Sulfides Glucocorticoids Treatment Outcome Middle Aged Severity of Illness Index Cyclopropanes Antibodies, Monoclonal Injections, Subcutaneous Humans Double-Blind Method Female Adult
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Vector representations of multi-word terms for semantic relatedness.

Journal of biomedical informatics Dec 13, 2017
This paper presents a comparison between several multi-word term aggregation methods of distributional context vectors applied to the task of semantic similarity and relatedness in the biomedical domain. We compare the multi-word term aggregation met...
Natural Language Processing Semantics Unified Medical Language System Machine Learning Reproducibility of Results Biomedical Research Humans
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Differential Compound Prioritization via Bidirectional Selectivity Push with Power.

Journal of chemical information and modeling Dec 13, 2017
Effective in silico compound prioritization is a critical step to identify promising drug candidates in the early stages of drug discovery. Current computational methods for compound prioritization usually focus on ranking the compounds based on one ...
Animals Humans Structure-Activity Relationship Drug Discovery Models, Biological Machine Learning Computer Simulation
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Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum.

Journal of visualized experiments : JoVE Dec 13, 2017
For a biosensing platform to have clinical relevance in point-of-care (POC) settings, assay sensitivity, reproducibility, and ability to reliably monitor analytes against the background of human serum are crucial. Nanoimprinting lithography (NIL) was...
Surface Plasmon Resonance Optical Rotation Biomarkers Humans Sensitivity and Specificity Troponin T
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The Multi-Attribute Group Decision-Making Method Based on Interval Grey Trapezoid Fuzzy Linguistic Variables.

International journal of environmental research and public health Dec 13, 2017
With respect to multi-attribute group decision-making (MAGDM) problems, where attribute values take the form of interval grey trapezoid fuzzy linguistic variables (IGTFLVs) and the weights (including expert and attribute weight) are unknown, improved...
Fuzzy Logic Decision Making Linguistics Group Processes Humans
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Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial.

Clinical nutrition (Edinburgh, Scotland) Dec 12, 2017
BACKGROUND & AIMS: Melatonin may benefit diabetic people with coronary heart disease (CHD) through its beneficial effects on biomarkers of oxidative stress and cardio-metabolic risk. This investigation evaluated the effects of melatonin administratio...
Coronary Disease Melatonin Nitric Oxide Humans Malondialdehyde C-Reactive Protein Aged Cholesterol, HDL Aged, 80 and over Glutathione Biomarkers Blood Pressure Female Diabetes Mellitus, Type 2 Double-Blind Method Male Insulin Antioxidants Middle Aged Oxidative Stress Blood Glucose
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Identification of human circadian genes based on time course gene expression profiles by using a deep learning method.

Biochimica et biophysica acta. Molecular basis of disease Dec 12, 2017
Circadian genes express periodically in an approximate 24-h period and the identification and study of these genes can provide deep understanding of the circadian control which plays significant roles in human health. Although many circadian gene ide...
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Databases, Genetic Circadian Rhythm Gene Expression Profiling Transcriptome Humans Machine Learning
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Distinguishing three subtypes of hematopoietic cells based on gene expression profiles using a support vector machine.

Biochimica et biophysica acta. Molecular basis of disease Dec 12, 2017
Hematopoiesis is a complicated process involving a series of biological sub-processes that lead to the formation of various blood components. A widely accepted model of early hematopoiesis proceeds from long-term hematopoietic stem cells (LT-HSCs) to...
Gene Expression Profiling Transcriptome Support Vector Machine Databases, Genetic Humans Gene Expression Regulation Hematopoietic Stem Cells
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Estimating causal effects for survival (time-to-event) outcomes by combining classification tree analysis and propensity score weighting.

Journal of evaluation in clinical practice Dec 12, 2017
RATIONALE, AIMS AND OBJECTIVES: A common approach to assessing treatment effects in nonrandomized studies with time-to-event outcomes is to estimate propensity scores and compute weights using logistic regression, test for covariate balance, and then...
Survival Analysis Proportional Hazards Models Propensity Score Monte Carlo Method Heart Failure Sex Factors Patient Readmission Comorbidity Pulmonary Disease, Chronic Obstructive Decision Trees Humans Time Factors Male Health Services Age Factors Machine Learning Socioeconomic Factors Middle Aged Models, Statistical Female
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Breast cancer data analysis for survivability studies and prediction.

Computer methods and programs in biomedicine Dec 12, 2017
BACKGROUND: Breast cancer is the most common cancer affecting females worldwide. Breast cancer survivability prediction is challenging and a complex research task. Existing approaches engage statistical methods or supervised machine learning to asses...
SEER Program Breast Neoplasms Survival Analysis Cohort Studies Models, Theoretical Humans Cluster Analysis Machine Learning Female
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