AIMC Topic: Humans

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Detecting genetic interactions with visible neural networks.

Communications biology
Non-linear interactions among single nucleotide polymorphisms (SNPs), genes, and pathways play an important role in human diseases, but identifying these interactions is a challenging task. Neural networks are state-of-the-art predictors in many doma...

Interpretable machine learning models for predicting childhood myopia from school-based screening data.

Scientific reports
This study assessed the efficacy of various diagnostic indicators and machine learning (ML) models in predicting childhood myopia. A total of 2,365 children aged 5-12 years were included in the study. The participants were exposed to non-cycloplegic ...

Machine learning and multi-omics analysis reveal key regulators of proneural-mesenchymal transition in glioblastoma.

Scientific reports
Glioblastoma (GBM) is classified into subtypes according to the molecular expression profile; the proneural subtype has a relatively good prognosis, and the mesenchymal type is the most aggressive form with the worst prognosis. GBM undergoes proneura...

A method for spatial interpretation of weakly supervised deep learning models in computational pathology.

Scientific reports
Deep learning enables the modelling of high-resolution histopathology whole-slide images (WSI). Weakly supervised learning of tile-level data is typically applied for tasks where labels only exist on the patient or WSI level (e.g. patient outcomes or...

Predicting carbapenem-resistant Pseudomonas aeruginosa infection risk using XGBoost model and explainability.

Scientific reports
The prevalence and spread of carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a global public health problem. This study aims to identify the risk factors of CRPA infection and construct a machine learning model to provide a prediction tool for ...

A 3D lightweight network with Roberts edge enhancement model (LR-Net) for brain tumor segmentation.

Scientific reports
In clinical medicine, a reliable and resource-friendly computer-aided diagnosis (CAD) method for brain tumor segmentation is essential to enhance diagnostic accuracy and therapeutic outcomes, particularly in regions with uneven healthcare resource di...

Machine learning-based integration develops relapse related signature for predicting prognosis and indicating immune microenvironment infiltration in breast cancer.

Scientific reports
Breast cancer is the most common type of cancer in women, and while current treatments can cure the majority of early-stage primary BC cases, recurrence remains a significant challenge. Traditional methods of assessing patient prognosis, such as AJCC...

Enhancing pancreatic cancer detection in CT images through secretary wolf bird optimization and deep learning.

Scientific reports
The pancreas is a gland in the abdomen that helps to produce hormones and digest food. The irregular development of tissues in the pancreas is termed as pancreatic cancer. Identification of pancreatic tumors early is significant for enhancing surviva...

GNNs surpass transformers in tumor medical image segmentation.

Scientific reports
To assess the suitability of Transformer-based architectures for medical image segmentation and investigate the potential advantages of Graph Neural Networks (GNNs) in this domain. We analyze the limitations of the Transformer, which models medical i...

Harnessing vaginal inflammation and microbiome: a machine learning model for predicting IVF success.

NPJ biofilms and microbiomes
Humans are the only species with a commensal Lactobacillus-dominant vaginal microbiota. Reproductive tract microbes have been linked to fertility outcomes, as has intrauterine inflammation, suggesting immune response may mediate adverse outcomes. In ...