AIMC Topic: Humans

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The hermeneutic window and machine-based interactions in primary care: how do we prevent depersonalisation?

The British journal of general practice : the journal of the Royal College of General Practitioners
BACKGROUND: Digital technologies are transforming healthcare delivery by enhancing accessibility and providing innovative ways to manage increasing patient demand. With the rise of artificial intelligence (AI) and machine learning (ML), a tsunami of ...

Artificial intelligence in primary care: a plausible prospect or distant delusion?

The British journal of general practice : the journal of the Royal College of General Practitioners
BACKGROUND: Artificial intelligence (AI) offers an innovative means of changing primary care, yet the impressions of primary care professionals (PCPs) on this potentially revolutionary resource remains unclear.

Landscape of essential growth and fluconazole-resistance genes in the human fungal pathogen Cryptococcus neoformans.

PLoS biology
Fungi can cause devastating invasive infections, typically in immunocompromised patients. Treatment is complicated both by the evolutionary similarity between humans and fungi and by the frequent emergence of drug resistance. Studies in fungal pathog...

Applying computational protein design to therapeutic antibody discovery - current state and perspectives.

Frontiers in immunology
Machine learning applications in protein sciences have ushered in a new era for designing molecules in silico. Antibodies, which currently form the largest group of biologics in clinical use, stand to benefit greatly from this shift. Despite the prol...

Metabolic profiles in laryngeal cancer defined two distinct molecular subtypes with divergent prognoses.

Frontiers in immunology
BACKGROUND: Laryngeal cancer (LCA) is the second most common type of head and neck malignancy, characterized by high recurrence rates and poor overall survival (OS). However, progress in curing LCA through molecular-targeted diagnostics and therapies...

Single-cell and bulk transcriptome analyses reveal elevated amino acid metabolism promoting tumor-directed immune evasion in colorectal cancer.

Frontiers in immunology
INTRODUCTION: Colorectal cancer (CRC), the third most common cancer worldwide, often shows limited responsiveness to immunotherapy due to its predominantly immune-excluded phenotype. Despite increasing insights into the complex tumor microenvironment...

Transcriptomic insights into the mechanism of action of telomere-related biomarkers in rheumatoid arthritis.

Frontiers in immunology
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune inflammatory disease. The mechanism by which telomeres are involved in the development of RA remains unclear. This study aimed to investigate the relationship between RA and telomeres.

An improved Red-billed blue magpie feature selection algorithm for medical data processing.

PloS one
Feature selection is a crucial preprocessing step in the fields of machine learning, data mining and pattern recognition. In medical data analysis, the large number and complexity of features are often accompanied by redundant or irrelevant features,...

EFCRFNet: A novel multi-scale framework for salient object detection.

PloS one
Salient Object Detection (SOD) is a fundamental task in computer vision, aiming to identify prominent regions within images. Traditional methods and deep learning-based models often encounter challenges in capturing crucial information in complex sce...

Influence of the CONCERN Early Warning System on Unanticipated ICU Transfers, In-Hospital Mortality, and Length of Stay: Results from a Multi-site Pragmatic Randomized Controlled Clinical Trial.

AMIA ... Annual Symposium proceedings. AMIA Symposium
Communicating Narrative Concerns Entered by RNs Early Warning System (CONCERN EWS) is a machine-learning predictive model that leverages nursing surveillance documentation patterns to predict deterioration risks for hospitalized patients. In a retros...