International journal of molecular sciences
Apr 18, 2025
Hepatocellular carcinoma (HCC) is a major complication of tyrosinemia type 1 (HT-1), an inborn error of metabolism affecting tyrosine catabolism. The risk of HCC is higher in late diagnoses despite treatment. Alpha-fetoprotein (AFP) is widely used to...
Exclusive breastfeeding (EBF) plays a crucial role in infant gut microbiome assembly and development. However, few studies have investigated the effects of EBF in restoring a perturbed microbiome. In this study, we applied whole metagenomic sequencin...
OBJECTIVES: To validate clinical scores [Testicular Workup for Ischemia and Suspected Torsion (TWIST), testicular torsion (TT) score, Artificial Intelligence-based Score (AIS), Boettcher Alert Score (BALS)] when evaluating children under 18 with non-...
BACKGROUND: Rotavirus is the leading cause of severe dehydrating diarrhea in children under 5 years worldwide. Timely diagnosis is critical, but access to confirmatory testing is limited in hospital settings. Machine learning (ML) models have shown p...
Research investigating the prenatal chemical exposome and child neurodevelopment has typically focused on a limited number of chemical exposures and controlled for sociodemographic factors and maternal mental health. Emerging machine learning approac...
BACKGROUND: Allergic rhinitis is a common disease that can affect the health of patients and bring huge social and economic burdens. In this study, we developed a model to predict the incidence rate of allergic rhinitis so as to provide accurate info...
OBJECTIVES: This study aimed to evaluate the performance of an artificial intelligence (AI)-based software for fracture detection in pediatric patients within a real-life clinical setting. Specifically, it sought to assess (1) the stand-alone AI perf...
PURPOSE: To evaluate the impact of an AI-based, noise reduction technique for compensation of image degradation on pediatric and neonatal chest and abdomen radiography using a visual grading analysis.
Early diagnosis and access to resources, support and therapy are critical for improving long-term outcomes for children with autism spectrum disorder (ASD). ASD is typically detected using a case-finding approach based on symptoms and family history,...
UNLABELLED: This study aimed to develop and validate a risk prediction model for moderate to severe bleeding in children with immune thrombocytopenia (ITP). Data from 286 ITP patients were prospectively collected and randomly split into training (80%...
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