AIMC Topic: Insulin Resistance

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Cognitively impaired elderly exhibit insulin resistance and no memory improvement with infused insulin.

Neurobiology of aging
Insulin resistance is a risk factor for Alzheimer's disease (AD), although its role in AD etiology is unclear. We assessed insulin resistance using fasting and insulin-stimulated measures in 51 elderly subjects with no dementia (ND; n = 37) and with ...

Evaluation of insulin sensitivity temporal prediction by using quantile regression combined with neural network model.

International journal of medical informatics
BACKGROUND: Stress-induced hyperglycemia, a pathologically high blood glucose level, is a frequent complication in intensive care units. Blood glucose (BG) level control is crucial but challenging due to patient variability. The Stochastic TARgeted (...

Prediction Model for Insulin Resistance and Implications for MASLD in Youth: A Novel Marker, the Pediatric Insulin Resistance Assessment Score.

Yonsei medical journal
PURPOSE: Insulin resistance (IR) is a condition closely associated with cardiovascular risk factors and metabolic dysfunction-associated steatotic liver disease (MASLD) is emerging as a significant IR-related complication. We aimed to develop a predi...

Prediction of Insulin Resistance in Nondiabetic Population Using LightGBM and Cohort Validation of Its Clinical Value: Cross-Sectional and Retrospective Cohort Study.

JMIR medical informatics
BACKGROUND: Insulin resistance (IR), a precursor to type 2 diabetes and a major risk factor for various chronic diseases, is becoming increasingly prevalent in China due to population aging and unhealthy lifestyles. Current methods like the gold-stan...

Exploring the effect of the triglyceride-glucose index on bone metabolism in prepubertal children, a retrospective study: insights from traditional methods and machine-learning-based bone remodeling prediction.

PeerJ
BACKGROUND: Childhood obesity poses a significant risk to bone health, but the impact of insulin resistance (IR) on bone metabolism in prepubertal children, as assessed by the triglyceride-glucose (TyG) index, remains underexplored. Bone turnover mar...

Machine learning-based clustering identifies obesity subgroups with differential multi-omics profiles and metabolic patterns.

Obesity (Silver Spring, Md.)
OBJECTIVE: Individuals living with obesity are differentially susceptible to cardiometabolic diseases. We hypothesized that an integrative multi-omics approach might improve identification of subgroups of individuals with obesity who have distinct ca...

[Antidiabetic role of high density lipoproteins].

Biomeditsinskaia khimiia
Disturbance in lipid metabolism can be both a cause and a consequence of the development of diabetes mellitus (DM). One of the most informative indicator of lipid metabolism is the ratio of atherogenic and antiatherogenic fractions of lipoproteins an...

Thyroid disorders in obese patients. Does insulin resistance make a difference?

Archives of endocrinology and metabolism
OBJECTIVE: The aim of this study was to evaluate the association between insulin resistance and thyroid pathology in obese patients, and compare the results between insulin-resistant and noninsulin-resistant patients.