OBJECTIVES: Circulating insulin concentrations mediate vascular-inflammatory and prothrombotic factors. However, it is unknown whether interindividual differences in circulating insulin levels are associated with different inflammatory and prothrombo...
Increasing evidence shows that hypothalamic dysfunction, insulin resistance, and weight loss precede and progress along with the cognitive decline in sporadic Alzheimer's Disease (AD) with sex differences. This study aimed to determine the effect of ...
BACKGROUND AND OBJECTIVE: Clinical characteristics of obesity are heterogenous, but current classification for diagnosis is simply based on BMI or metabolic healthiness. The purpose of this study was to use machine learning to explore a more precise ...
Type 1 diabetes is a chronic disease caused by the inability of the pancreas to produce insulin. Patients suffering type 1 diabetes depend on the appropriate estimation of the units of insulin they have to use in order to keep blood glucose levels in...
Advanced materials (Deerfield Beach, Fla.)
34532914
Oral administration is the most convenient and commonly used approach for drug delivery, while it is still a challenge to overcome the complicated gastrointestinal barriers and realize efficient macromolecular drug absorption. Here, novel magneto-res...
Journal of the American Medical Informatics Association : JAMIA
34279615
OBJECTIVE: The study sought to determine whether machine learning can predict initial inpatient total daily dose (TDD) of insulin from electronic health records more accurately than existing guideline-based dosing recommendations.
Current artificial pancreas (AP) systems are hybrid closed-loop systems that require manual meal announcements to manage postprandial glucose control effectively. This poses a cognitive burden and challenge to users with T1D since this relies on freq...
Traceless physical cues are desirable for remote control of the in situ production and real-time dosing of biopharmaceuticals in cell-based therapies. However, current optogenetic, magnetogenetic, or electrogenetic devices require sophisticated elect...
In this study, a novel approach is proposed for glucose regulation in type-I diabetes patients. Unlike most studies, the glucose-insulin metabolism is considered to be uncertain. A new approach on the basis of the Immersion and Invariance (I&I) theor...
Journal of diabetes science and technology
36562599
BACKGROUND: Real-world studies of people with type 2 diabetes (T2D) have shown insufficient dose adjustment during basal insulin titration in clinical practice leading to suboptimal treatment. Thus, 60% of people with T2D treated with insulin do not ...