AIMC Topic: Interleukin-17

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Decoding chronic stress: From behavioral-molecular dynamics in mice to clinical implications of cortisol and IL-17 in depression severity.

Journal of affective disorders Sep 15, 2025
BACKGROUNDS: The etiology of depression involves chronic stress, a recognized determinant of onset and severity. This study adopts a translational approach, utilizing a mouse model and a clinical cohort to explore the relationship between chronic str...
Stress, Psychological Interleukin-17 Severity of Illness Index Depression Mice, Inbred C57BL Chronic Disease Mice Disease Models, Animal Adult Animals Male Middle Aged Biomarkers Female Machine Learning Humans Hydrocortisone
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Knockdown of CDKN1A Suppresses the IL-17 Pathway to Inhibit Oxidative Stress and Alleviate Autism Spectrum Disorder.

Journal of biochemical and molecular toxicology Sep 1, 2025
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by impaired social interaction, communication deficits, and repetitive behaviors. However, the underlying molecular mechanisms remain elusive. This study aims to i...
Rats, Sprague-Dawley Disease Models, Animal Rats Signal Transduction Microglia Gene Knockdown Techniques Cyclin-Dependent Kinase Inhibitor p21 Lipopolysaccharides Autism Spectrum Disorder Male Oxidative Stress Animals Interleukin-17 Mice
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[Role of interleukin-17 in alveolar fluid clearance in mice with acute lung injury].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University Apr 20, 2016
OBJECTIVE: To investigate the role of interleukin-17 (IL-17) in alveolar fluid clearance in mice with acute lung injury (ALI) and explore the possible mechanism.
AMP-Activated Protein Kinases Lung Mice Acute Lung Injury Bronchoalveolar Lavage Fluid Lipopolysaccharides Interleukin-17 Gene Knockout Techniques Protein Serine-Threonine Kinases Epithelial Sodium Channels Animals Interleukin-8
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[Prophylactic administration of all-trans retinoic acid alleviates inflammation in rats with collagen-induced arthritis].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University Feb 20, 2016
OBJECTIVE: To investigate the effects of prophylactic administration of all-trans retinoic acid (ATRA) in relieving inflammation in a rat model of collagen-induced arthritis (CIA).
Rats Inflammation Tumor Necrosis Factor-alpha Lipids Female Tretinoin Interleukin-10 T-Lymphocytes, Regulatory Matrix Metalloproteinase 3 Interleukin-17 Rats, Wistar ADAMTS4 Protein Animals Collagen Type II Th17 Cells Freund's Adjuvant Arthritis, Experimental
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