AIMC Topic: Lab-On-A-Chip Devices
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Low-cost robotic manipulation of live microtissues for cancer drug testing.
Science advances
May 16, 2025
The scarcity of human biopsies available for drug testing is a paramount challenge for developing therapeutics, disease models, and personalized treatments. Microtechnologies that combine the microscale manipulation of tissues and fluids offer the ex...
Artificial intelligence enhanced microfluidic system for multiplexed point-of-care-testing of biological thiols.
Talanta
May 15, 2025
Cysteamine (CA) serves as a cystine-depleting agent employed in the management of cystinosis and a range of other medical conditions. Monitoring blood CA levels at the point of care is imperative due to the risk of toxicity associated with elevated C...
Point-of-Care Testing: The Convergence of Innovation and Accessibility in Diagnostics.
Analytical chemistry
May 13, 2025
Over the years, the evolution of point-of-care testing (POCT) has been driven by technological advancements in materials, design, and artificial intelligence, as well as breakthrough developments in wearable technologies. These innovations are shifti...
Validation of a Microfluidic Device Prototype for Cancer Detection and Identification: Circulating Tumor Cells Classification Based on Cell Trajectory Analysis Leveraging Cell-Based Modeling and Machine Learning.
International journal for numerical methods in biomedical engineering
Apr 1, 2025
Microfluidic devices (MDs) present a novel method for detecting circulating tumor cells (CTCs), enhancing the process through targeted techniques and visual inspection. However, current approaches often yield heterogeneous CTC populations, necessitat...
Understanding the Manufacturing Process of Lipid Nanoparticles for mRNA Delivery Using Machine Learning.
Chemical & pharmaceutical bulletin
Jan 1, 2024
Lipid nanoparticles (LNPs), used for mRNA vaccines against severe acute respiratory syndrome coronavirus 2, protect mRNA and deliver it into cells, making them an essential delivery technology for RNA medicine. The LNPs manufacturing process consists...
Artificial intelligence velocimetry and microaneurysm-on-a-chip for three-dimensional analysis of blood flow in physiology and disease.
Proceedings of the National Academy of Sciences of the United States of America
Mar 30, 2021
Understanding the mechanics of blood flow is necessary for developing insights into mechanisms of physiology and vascular diseases in microcirculation. Given the limitations of technologies available for assessing in vivo flow fields, in vitro method...
Shape anisotropy-governed locomotion of surface microrollers on vessel-like microtopographies against physiological flows.
Proceedings of the National Academy of Sciences of the United States of America
Mar 30, 2021
Surface microrollers are promising microrobotic systems for controlled navigation in the circulatory system thanks to their fast speeds and decreased flow velocities at the vessel walls. While surface propulsion on the vessel walls helps minimize the...
Heterogeneous sensing in a multifunctional soft sensor for human-robot interfaces.
Science robotics
Dec 16, 2020
Soft sensors have been playing a crucial role in detecting different types of physical stimuli to part or the entire body of a robot, analogous to mechanoreceptors or proprioceptors in biology. Most of the currently available soft sensors with compac...
AI on a chip.
Lab on a chip
Aug 26, 2020
Artificial intelligence (AI) has dramatically changed the landscape of science, industry, defence, and medicine in the last several years. Supported by considerably enhanced computational power and cloud storage, the field of AI has shifted from most...
A ferrobotic system for automated microfluidic logistics.
Science robotics
Feb 26, 2020
Automated technologies that can perform massively parallelized and sequential fluidic operations at small length scales can resolve major bottlenecks encountered in various fields, including medical diagnostics, -omics, drug development, and chemical...
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