AIMC Topic: Lab-On-A-Chip Devices

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Ear-Bot: Locust Ear-on-a-Chip Bio-Hybrid Platform.

Sensors (Basel, Switzerland)
During hundreds of millions of years of evolution, insects have evolved some of the most efficient and robust sensing organs, often far more sensitive than their man-made equivalents. In this study, we demonstrate a hybrid bio-technological approach,...

A Machine Learning-Assisted Nanoparticle-Printed Biochip for Real-Time Single Cancer Cell Analysis.

Advanced biosystems
Cancers are a complex conglomerate of heterogeneous cell populations with varying genotypes and phenotypes. The intercellular heterogeneity within the same tumor and intratumor heterogeneity within various tumors are the leading causes of resistance ...

Droplet size prediction in a microfluidic flow focusing device using an adaptive network based fuzzy inference system.

Biomedical microdevices
Microfluidics has wide applications in different technologies such as biomedical engineering, chemistry engineering, and medicine. Generating droplets with desired size for special applications needs costly and time-consuming iterations due to the no...

Discriminating between sleep and exercise-induced fatigue using computer vision and behavioral genetics.

Journal of neurogenetics
Following prolonged swimming, cycle between active swimming bouts and inactive quiescent bouts. Swimming is exercise for and here we suggest that inactive bouts are a recovery state akin to fatigue. It is known that cGMP-dependent kinase (PKG) acti...

Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography.

Journal of visualized experiments : JoVE
Brain metastases are the most lethal cancer lesions; 10-30% of all cancers metastasize to the brain, with a median survival of only ~5-20 months, depending on the cancer type. To reduce the brain metastatic tumor burden, gaps in basic and translation...

Converging Multidimensional Sensor and Machine Learning Toward High-Throughput and Biorecognition Element-Free Multidetermination of Extracellular Vesicle Biomarkers.

ACS sensors
Extracellular vesicles (EVs) are a frontier class of circulating biomarkers for the diagnosis and prognosis of different diseases. These lipid structures afford various biomarkers such as the concentrations of the EVs () themselves and carried protei...

Synapse cell optimization and back-propagation algorithm implementation in a domain wall synapse based crossbar neural network for scalable on-chip learning.

Nanotechnology
On-chip learning in spin orbit torque driven domain wall synapse based crossbar fully connected neural network (FCNN) has been shown to be extremely efficient in terms of speed and energy, when compared to training on a conventional computing unit or...

Intelligent classification of platelet aggregates by agonist type.

eLife
Platelets are anucleate cells in blood whose principal function is to stop bleeding by forming aggregates for hemostatic reactions. In addition to their participation in physiological hemostasis, platelet aggregates are also involved in pathological ...

DeLTA: Automated cell segmentation, tracking, and lineage reconstruction using deep learning.

PLoS computational biology
Microscopy image analysis is a major bottleneck in quantification of single-cell microscopy data, typically requiring human oversight and curation, which limit both accuracy and throughput. To address this, we developed a deep learning-based image an...

Applications of machine learning for simulations of red blood cells in microfluidic devices.

BMC bioinformatics
BACKGROUND: For optimization of microfluidic devices for the analysis of blood samples, it is useful to simulate blood cells as elastic objects in flow of blood plasma. In such numerical models, we primarily need to take into consideration the moveme...