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Population pharmacokinetic/pharmacodynamic assessment of pharmacological effect of a selective estrogen receptor β agonist on total testosterone in healthy men.

Clinical pharmacology in drug development Jun 8, 2015
BACKGROUND: LY500307 is a highly selective estrogen receptor β (ERβ) agonist, which loses its selectivity at high dose and leads to undesirable suppression of total testosterone (TT) concentration. The objective of the present analysis was to define ...
Drug Administration Schedule Estrogen Receptor beta Fourier Analysis Healthy Volunteers Nonlinear Dynamics Benzopyrans London Testosterone Adult Selective Estrogen Receptor Modulators Single-Blind Method Male Models, Biological Humans Middle Aged Biomarkers Young Adult Circadian Rhythm Administration, Oral Cross-Over Studies
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Seven Opportunities for Artificial Intelligence in Primary Care Electronic Visits: Qualitative Study of Staff and Patient Views.

Annals of family medicine May 27, 2025
PURPOSE: Increased workload associated with electronic visits (eVisits) in primary care could potentially be decreased by the use of artificial intelligence (AI); however, it is unknown whether this use of AI would be acceptable to staff and patients...
Male Middle Aged England Female Aged Adult Primary Health Care Workload London Humans Focus Groups Artificial Intelligence Qualitative Research Attitude of Health Personnel Interviews as Topic
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Early Identification of Trauma-induced Coagulopathy: Development and Validation of a Multivariable Risk Prediction Model.

Annals of surgery Dec 1, 2021
OBJECTIVE: The aim of this study was to develop and validate a risk prediction tool for trauma-induced coagulopathy (TIC), to support early therapeutic decision-making.
Humans Prospective Studies Aged, 80 and over Adult Male Clinical Decision-Making Female Aged Blood Coagulation Disorders Predictive Value of Tests Wounds and Injuries Bayes Theorem London Supervised Machine Learning Trauma Severity Indices Middle Aged Risk Assessment Adolescent
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Using Natural Language Processing on Electronic Health Records to Enhance Detection and Prediction of Psychosis Risk.

Schizophrenia bulletin Mar 16, 2021
BACKGROUND: Using novel data mining methods such as natural language processing (NLP) on electronic health records (EHRs) for screening and detecting individuals at risk for psychosis.
London Models, Statistical Natural Language Processing Psychotic Disorders Adult Male Middle Aged Risk Assessment Adolescent Follow-Up Studies Electronic Health Records Female Young Adult Humans Retrospective Studies
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Validation of artificial neural networks as a methodology for donor-recipient matching for liver transplantation.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society Feb 1, 2018
In 2014, we reported a model for donor-recipient (D-R) matching in liver transplantation (LT) based on artificial neural networks (ANNs) from a Spanish multicenter study (Model for Allocation of Donor and Recipient in España [MADR-E]). The aim is to ...
London Decision Support Techniques Computer Simulation Female Reproducibility of Results Risk Factors Adult Humans Neural Networks, Computer Algorithms Time Factors Male Liver Diseases Graft Survival ROC Curve Middle Aged Donor Selection Liver Transplantation Treatment Outcome Tissue Donors Risk Assessment Waiting Lists Area Under Curve
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Google reveals secret test of AI bot to beat top Go players.

Nature Jan 4, 2017
Competitive Behavior Games, Experimental Software Games, Recreational Internet London Artificial Intelligence
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