Ubiquitous per- and poly-fluoroalkyl substances (PFAS) threaten human's health and attract worldwide attention. PFAS-mediated toxicity involves adverse effects of PFAS on proteins, and assessment of PFAS-protein binding interactions helps to explain ...
O-methylguanine-DNA methyltransferase (MGMT) promoter methylation is a crucial biomarker in glioblastoma (GBM) that influences response to temozolomide. Traditional detection methods, such as gene sequencing, are time-consuming and limited to postope...
We propose a guided registration method for spatially aligning a fixed preoperative image and untracked ultrasound image slices. We exploit the unique interactive and spatially heterogeneous nature of this application to develop a registration algori...
BACKGROUND: Ovarian cancer (OC), owing to its substantial heterogeneity and high invasiveness, has historically been devoid of precise, individualized treatment options. This study aimed to establish integrated consensus subtypes of OC using differen...
OBJECTIVES: To evaluate the predictive performance of different data sources to forecast fatal overdose in Rhode Island neighborhoods, with the goal of providing a template for other jurisdictions interested in predictive analytics to direct overdose...
In recent years, machine learning-based handwriting analysis has emerged as a valuable tool for supporting the early diagnosis of Alzheimer's disease and predicting its progression. Traditional approaches represent handwriting tasks using a single fe...
Analytical and bioanalytical chemistry
Mar 29, 2025
This study proposes a rapid identification method for foodborne pathogens by combining Raman spectroscopy with explainable machine learning. Spectral data of nine common foodborne pathogens are collected using a laser confocal Raman spectrometer, and...
Simultaneous identification of natural and chemically modified DNA nucleotides at molecular resolution remains a pivotal challenge in genomic science. Despite significant advances in current sequencing technologies, the ability to identify subtle cha...
Acute pancreatitis (AP) presents a significant clinical challenge due to its wide range of severity, from mild cases to life-threatening complications such as severe acute pancreatitis (SAP), necrosis, and multi-organ failure. Traditional scoring sys...
Circulating tumor cells (CTCs) are vital indicators of metastasis and provide a non-invasive method for early cancer diagnosis, prognosis, and therapeutic monitoring. However, their low prevalence and heterogeneity in the bloodstream pose significant...
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