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Novel AT2 Cell Subpopulations and Diagnostic Biomarkers in IPF: Integrating Machine Learning with Single-Cell Analysis.

International journal of molecular sciences
Idiopathic pulmonary fibrosis (IPF) is a long-term condition with an unidentified cause, and currently there are no specific treatment options available. Alveolar epithelial type II cells (AT2) constitute a heterogeneous population crucial for secret...

Treatment with robot-assisted gait trainer Walkbot along with physiotherapy vs. isolated physiotherapy in children and adolescents with cerebral palsy. Experimental study.

BMC neurology
BACKGROUND: Improving walking ability is a key objective in the treatment of children and adolescents with cerebral palsy, since it directly affects their activity and participation. In recent years, robotic technology has been implemented in gait tr...

Detecting depression severity using weighted random forest and oxidative stress biomarkers.

Scientific reports
This study employs machine learning to detect the severity of major depressive disorder (MDD) through binary and multiclass classifications. We compared models that used only biomarkers of oxidative stress with those that incorporate sociodemographic...

Promoting safety of underground machinery operators through participatory ergonomics and fuzzy model analysis to foster sustainable mining practices.

Scientific reports
One of the most vital parameters to achieve sustainability in any field is encompassing the Occupational Health and Safety (OHS) of the workers. In mining industry where heavy earth moving machineries are largely employed, ergonomic hazards turn out ...

Deep learning application of vertebral compression fracture detection using mask R-CNN.

Scientific reports
Vertebral compression fractures (VCFs) of the thoracolumbar spine are commonly caused by osteoporosis or result from traumatic events. Early diagnosis of vertebral compression fractures can prevent further damage to patients. When assessing these fra...

Efficient segmentation of active and inactive plaques in FLAIR-images using DeepLabV3Plus SE with efficientnetb0 backbone in multiple sclerosis.

Scientific reports
This research paper introduces an efficient approach for the segmentation of active and inactive plaques within Fluid-attenuated inversion recovery (FLAIR) images, employing a convolutional neural network (CNN) model known as DeepLabV3Plus SE with th...

Decoding depression: a comprehensive multi-cohort exploration of blood DNA methylation using machine learning and deep learning approaches.

Translational psychiatry
The causes of depression are complex, and the current diagnosis methods rely solely on psychiatric evaluations with no incorporation of laboratory biomarkers in clinical practices. We investigated the stability of blood DNA methylation depression sig...

[Medicine of the future: the role of artificial intelligence in optimizing nutrition for the health of the Russian population].

Voprosy pitaniia
One of the most pressing medical, social and government tasks is to ensure health saving, improve the quality of life and increase the life expectancy of the Russian population. The most important lever to ensure the solution of these issues is the o...

Developing a machine learning-based prognosis and immunotherapeutic response signature in colorectal cancer: insights from ferroptosis, fatty acid dynamics, and the tumor microenvironment.

Frontiers in immunology
INSTRUCTION: Colorectal cancer (CRC) poses a challenge to public health and is characterized by a high incidence rate. This study explored the relationship between ferroptosis and fatty acid metabolism in the tumor microenvironment (TME) of patients ...

Effects of precise cardio sounds on the success rate of phonocardiography.

PloS one
This work investigates whether inclusion of the low-frequency components of heart sounds can increase the accuracy, sensitivity and specificity of diagnosis of cardiovascular disorders. We standardized the measurement method to minimize changes in si...