AIMC Topic: Membrane Proteins
Clear Filters Showing 1 to 10 of 122 articles
The EMC acts as a chaperone for membrane proteins.
Nature communications
Aug 2, 2025
Structure formation of membrane proteins is error-prone and thus requires chaperones that oversee this essential process in cell biology. The ER membrane protein complex (EMC) is well-defined as a transmembrane domain (TMD) insertase. In this study, ...
Prediction of pathogenic mutations in human transmembrane proteins and their associated diseases via utilizing pre-trained Bio-LLMs.
Communications biology
Jul 15, 2025
Missense mutations can disrupt the structure and function of membrane proteins, potentially impairing key biological processes and leading to various human diseases. However, existing computational methods primarily focus on binary pathogenicity clas...
Consensus structure prediction of A. thaliana's MCTP4 structure using prediction tools and coarse grained simulations of transmembrane domain dynamics.
PloS one
Jul 15, 2025
Multiple C2 Domains and Transmembrane region Proteins (MCTPs) in plants have been identified as important functional and structural components of plasmodesmata cytoplasmic bridges, which are vital for cell-cell communication. MCTPs are endoplasmic re...
Evaluation of Small-Molecule Binding Site Prediction Methods on Membrane-Embedded Protein Interfaces.
Journal of chemical information and modeling
Jul 2, 2025
Increasing structural and biophysical evidence suggests that many drug molecules bind to the protein-membrane interface region in membrane protein structures. An important starting point for drug discovery is the determination of a ligand's binding s...
Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors.
Nature communications
May 23, 2025
Despite the STING-type-I interferon pathway playing a key role in effective anti-tumor immunity, the therapeutic benefit of direct STING agonists appears limited. In this study, we use several artificial intelligence techniques and patient-based mult...
Discovering Novel Biomarkers and Potential Therapeutic Targets of Amyotrophic Lateral Sclerosis Through Integrated Machine Learning and Gene Expression Profiling.
Journal of molecular neuroscience : MN
Apr 30, 2025
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that has multiple factors that make its molecular pathogenesis difficult to understand and its diagnosis and treatment during the early stages difficult to determine. Dis...
CLIC1 and IFITM2 expression in brain tissue correlates with cognitive impairment via immune dysregulation in sepsis and Alzheimer's disease.
International immunopharmacology
Apr 10, 2025
BACKGROUND: Sepsis, a life-threatening condition driven by dysregulated host responses to infection, is associated with long-term cognitive impairments resembling Alzheimer's disease (AD). However, the molecular mechanisms linking sepsis-induced cogn...
NA_mCNN: Classification of Sodium Transporters in Membrane Proteins by Integrating Multi-Window Deep Learning and ProtTrans for Their Therapeutic Potential.
Journal of proteome research
Apr 7, 2025
Sodium transporters maintain cellular homeostasis by transporting ions, minerals, and nutrients across the membrane, and Na+/K+ ATPases facilitate the cotransport of solutes in neurons, muscle cells, and epithelial cells. Sodium transporters are impo...
Enhancing diagnostic accuracy for HBV-related cirrhosis progression: predictive modeling using combined Golgi protein 73 and α1-microglobulin for the transition from nondecompensated to decompensated cirrhosis.
European journal of gastroenterology & hepatology
Mar 21, 2025
BACKGROUND AND AIMS: Chronic hepatitis B poses a major health risk, especially its progression to decompensated cirrhosis. Early prediction is crucial for better outcomes. This study evaluated the predictive power of Golgi protein 73 (GP73), α1-micro...
Machine Learning
Biomarkers
Female
Aged
Humans
Alanine Transaminase
Aspartate Aminotransferases
Alpha-Globulins
Liver Cirrhosis
Disease Progression
Adult
Hepatitis B, Chronic
Membrane Proteins
Case-Control Studies
Decision Trees
Male
Age Factors
Logistic Models
Predictive Value of Tests
Platelet Count
Middle Aged
Genome data based deep learning identified new genes predicting pharmacological treatment response of attention deficit hyperactivity disorder.
Translational psychiatry
Feb 7, 2025
Although the efficacy of pharmacy in the treatment of attention deficit/hyperactivity disorder (ADHD) has been well established, the lack of predictors of treatment response poses great challenges for personalized treatment. The current study employe...
Stay Ahead of Medical AI
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.
Subscribe NowPopular Topics
- Machine Learning 31984
- Neural Networks, Computer 30211
- Algorithms 27388
- Deep Learning 26888
- Artificial Intelligence 24826
- Robotics 13382
- Image Processing, Computer-Assisted 9732
- Retrospective Studies 9334
- Magnetic Resonance Imaging 6342
- Reproducibility of Results 5670
- Tomography, X-Ray Computed 4864
- Support Vector Machine 4766
- Computational Biology 4331
- Brain 4126
- Computer Simulation 3932
Recent Journals
- Scientific reports 6743
- Sensors (Basel, Switzerland) 4794
- PloS one 4196
- Neural networks : the official journal of the International Neural Network Society 3026
- Computational intelligence and neuroscience 1931
- Computers in biology and medicine 1916
- Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 1686
- Studies in health technology and informatics 1378
- IEEE journal of biomedical and health informatics 1170
- Journal of chemical information and modeling 1064
- Nature communications 1039
- Computer methods and programs in biomedicine 883
- Bioinformatics (Oxford, England) 873
- Journal of medical Internet research 860
- Briefings in bioinformatics 853