AIMC Topic: Mice

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Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis.

European journal of medicinal chemistry Dec 28, 2017
Bruton's tyrosine kinase (Btk) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) and Fcγ receptor (FcR) signaling pathways, which makes it a uniquely attractive target for the treatment of autoimmune diseases, such as rheum...
Pyrroles Dose-Response Relationship, Drug Cell Line Protein Kinase Inhibitors Protein-Tyrosine Kinases Pyrimidines Structure-Activity Relationship Agammaglobulinaemia Tyrosine Kinase Haplorhini Models, Molecular Molecular Structure Dogs Humans Microsomes, Liver Arthritis, Rheumatoid Animals Drug Design Rats Mice Cell Proliferation Rats, Sprague-Dawley
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Jobelyn attenuates inflammatory responses and neurobehavioural deficits associated with complete Freund-adjuvant-induced arthritis in mice.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Dec 27, 2017
Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects the physical and psychosocial wellbeing of the patients and a major cause of work disability. Current drugs for its treatment only provide palliative effect, as cure for the dis...
Edema Freund's Adjuvant Sorghum Tumor Necrosis Factor-alpha Arthritis, Experimental Interleukin-6 Animals Behavior, Animal Nervous System Diseases Male Quality of Life Oxidative Stress Mice Arthritis, Rheumatoid Plant Extracts Antioxidants Inflammation Anti-Inflammatory Agents
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Combining robotic training and inactivation of the healthy hemisphere restores pre-stroke motor patterns in mice.

eLife Dec 27, 2017
Focal cortical stroke often leads to persistent motor deficits, prompting the need for more effective interventions. The efficacy of rehabilitation can be increased by 'plasticity-stimulating' treatments that enhance experience-dependent modification...
Animals Mice Motor Activity Stroke Rehabilitation Disease Models, Animal Motor Cortex Recovery of Function Forelimb Robotics Dominance, Cerebral Stroke
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Deep vector-based convolutional neural network approach for automatic recognition of colonies of induced pluripotent stem cells.

PloS one Dec 27, 2017
Pluripotent stem cells can potentially be used in clinical applications as a model for studying disease progress. This tracking of disease-causing events in cells requires constant assessment of the quality of stem cells. Existing approaches are inad...
Neural Networks, Computer Induced Pluripotent Stem Cells Animals Support Vector Machine Mice Automation
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Aggregation-Induced Emission Probe for Specific Turn-On Quantification of Soluble Transferrin Receptor: An Important Disease Marker for Iron Deficiency Anemia and Kidney Diseases.

Analytical chemistry Dec 22, 2017
Transferrin receptor (TfR) is overexpressed on the surface of many cancer cells due to its vital roles in iron circulation and cellular respiration. Soluble transferrin receptor (sTfR), a truncated extracellular form of TfR in serum, is an important ...
Biomarkers Animals Peptides Cell Line, Tumor Humans Stilbenes Receptors, Transferrin NIH 3T3 Cells Luminescent Agents Mice Kidney Diseases Luminescent Measurements Anemia, Iron-Deficiency
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Cortical frequency-specific plasticity is independently induced by intracortical circuitry.

Neuroscience letters Dec 21, 2017
Auditory learning induces frequency-specific plasticity in the auditory cortex. Both the auditory cortex and thalamus are involved in the cortical plasticity; however, the precise role of the intracortical circuity remains unclear until the contribut...
Neuronal Plasticity Action Potentials Mice, Inbred C57BL Lidocaine Animals Thalamus Auditory Cortex Neurons Mice Evoked Potentials, Auditory Voltage-Gated Sodium Channel Blockers Acoustic Stimulation Electric Stimulation
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Cell ontology in an age of data-driven cell classification.

BMC bioinformatics Dec 21, 2017
BACKGROUND: Data-driven cell classification is becoming common and is now being implemented on a massive scale by projects such as the Human Cell Atlas. The scale of these efforts poses a challenge. How can the results be made searchable and accessib...
Biological Ontologies Cells Animals Mice Computational Biology Humans Models, Statistical Databases, Factual
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Gastro-protective effect of edible plant Artemisia argyi in ethanol-induced rats via normalizing inflammatory responses and oxidative stress.

Journal of ethnopharmacology Dec 20, 2017
PHARMACOLOGICAL RELEVANCE: Artemisia argyi, a kind of ethnic drug, has a long-term use on gastric diseases and syndromes.
Anti-Ulcer Agents Gastric Mucosa Stomach Ulcer RAW 264.7 Cells Rats, Wistar Free Radicals Malondialdehyde Cytoprotection Superoxide Dismutase Phytotherapy Artemisia Oxidative Stress Ethanol Disease Models, Animal Macrophages Plants, Medicinal Mice Anti-Inflammatory Agents Animals Inflammation Mediators Antioxidants Plant Extracts
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Elevation of serum pyruvate kinase M2 (PKM2) in IBD and its relationship to IBD indices.

Clinical biochemistry Dec 19, 2017
OBJECTIVES: Endoscopy remains the gold standard to diagnose and evaluate inflammatory bowel disease (IBD) activity. Current biomarkers or their combinations cannot adequately predict IBD risk, diagnosis, progression or relapse, and response to therap...
Caco-2 Cells RAW 264.7 Cells Pyruvate Kinase Biomarkers Inflammatory Bowel Diseases Female Adult Mice Gastrointestinal Microbiome Dysbiosis Animals Male Humans
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Role of serotonin in the intestinal mucosal epithelium barrier in weaning mice undergoing stress-induced diarrhea.

Journal of molecular histology Dec 19, 2017
Stress-induced diarrhea is a frequent and challenging threat to humans and domestic animals. Serotonin (5-HT) has been shown to be involved in the pathological process of stress-induced diarrhea. However, the role of 5-HT in stress-induced diarrhea r...
Animals Weaning Tight Junction Proteins Fenclonine Serotonin Stress, Psychological Serotonin Antagonists Diarrhea Mice Intestinal Mucosa
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