AIMC Topic: Mice
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Machine learning-aided discovery of T790M-mutant EGFR inhibitor CDDO-Me effectively suppresses non-small cell lung cancer growth.
Cell communication and signaling : CCS
Dec 5, 2024
BACKGROUND: Epidermal growth factor receptor (EGFR) T790M mutation often occurs during long durational erlotinib treatment of non-small cell lung cancer (NSCLC) patients, leading to drug resistance and disease progression. Identification of new selec...
Early colorectal cancer detection: a serum analysis platform combining SERS and machine learning.
Analytical methods : advancing methods and applications
Dec 5, 2024
Colorectal cancer (CRC) is one of the deadliest malignancies globally, with high incidence and mortality rates. Early detection is crucial for improving treatment success rates and patient survival. However, due to the difficulty in detecting early s...
Machine learning-based analysis of programmed cell death types and key genes in intervertebral disc degeneration.
Apoptosis : an international journal on programmed cell death
Dec 4, 2024
Intervertebral disc degeneration (IVDD) is intricately associated with various forms of programmed cell death (PCD). Identifying key PCD types and associated genes is essential for understanding the molecular mechanisms underlying IVDD and discoverin...
Identification of structural stability and fragility of mouse liver glycogen via label-free Raman spectroscopy coupled with convolutional neural network algorithm.
International journal of biological macromolecules
Dec 3, 2024
Glycogen structure is closely associated with its physiological functions. Previous studies confirmed that liver glycogen structure had two dominant states: mainly stable during the day and largely fragile at night. However, the diurnal change of gly...
Exploring an novel diagnostic gene of trastuzumab-induced cardiotoxicity based on bioinformatics and machine learning.
Scientific reports
Dec 3, 2024
Trastuzumab (Tra)-induced cardiotoxicity (TIC) is a serious side effect of cancer chemotherapy, which can seriously harm the health of cancer patients. However, there is currently a lack of effective and reliable biomarkers for the early diagnosis of...
High-content imaging and deep learning-driven detection of infectious bacteria in wounds.
Bioprocess and biosystems engineering
Dec 2, 2024
Fast and accurate detection of infectious bacteria in wounds is crucial for effective clinical treatment. However, traditional methods take over 24 h to yield results, which is inadequate for urgent clinical needs. Here, we introduce a deep learning-...
Identification of an immune-related gene panel for the diagnosis of pulmonary arterial hypertension using bioinformatics and machine learning.
International immunopharmacology
Nov 30, 2024
OBJECTIVE: This study aimed to screen an immune-related gene (IRG) panel and develop a novel approach for diagnosing pulmonary arterial hypertension (PAH) utilizing bioinformatics and machine learning (ML).
Accurate Spatial Heterogeneity Dissection and Gene Regulation Interpretation for Spatial Transcriptomics using Dual Graph Contrastive Learning.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Nov 28, 2024
Recent advances in spatial transcriptomics have enabled simultaneous preservation of high-throughput gene expression profiles and the spatial context, enabling high-resolution exploration of distinct regional characterization in tissue. To effectivel...
Detecting Collagen by Machine Learning Improved Photoacoustic Spectral Analysis for Breast Cancer Diagnostics: Feasibility Studies With Murine Models.
Journal of biophotonics
Nov 26, 2024
Collagen, a key structural component of the extracellular matrix, undergoes significant remodeling during carcinogenesis. However, the important role of collagen levels in breast cancer diagnostics still lacks effective in vivo detection techniques t...
Potential diagnostic biomarkers in heart failure: Suppressed immune-associated genes identified by bioinformatic analysis and machine learning.
European journal of pharmacology
Nov 23, 2024
Heart failure (HF) threatens tens of millions of people's health worldwide, which is the terminal stage in the development of majority cardiovascular diseases. Recently, an increasing number of studies have demonstrated that bioinformatics and machin...
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