Lung adenocarcinoma (LUAD) constitutes a major cause of cancer-related fatalities worldwide. Early identification of malignant pulmonary nodules constitutes the most effective approach to reducing the mortality of LUAD. Despite the wide application o...
ETHNOPHARMACOLOGICAL RELEVANCE: Various parts of Prunus persica (L.) Batsch (peach) exhibit medicinal properties and are utilized in traditional Chinese medicine (TCM) for therapeutic purposes. Notably, the root of P. persica, referred to as "taoshug...
Prenatal brain development is particularly sensitive to chemicals that can disrupt synapse formation and cause neurodevelopmental disorders. In most cases, such chemicals increase cellular oxidative stress. For example, prenatal exposure to the anti-...
Targeting ubiquitin E3 ligases is therapeutically attractive; however, the absence of an active-site pocket impedes computational approaches for identifying inhibitors. In a large, unbiased biochemical screen, we discover inhibitors that bind a crypt...
ETHNOPHARMACOLOGICAL RELEVANCE: Shengxuebao Mixture (SXB) is a traditional Chinese medicine which has been widely used on treating Chemotherapy-induced leukopenia and multiple anemia. It remains unclear whether SXB has a role in chemotherapeutic-indu...
ETHNOPHARMACOLOGICAL RELEVANCE: Alpinia japonica, a traditional herb utilized in Miao medicine in southwestern China, has been employed to alleviate symptoms such as stomachache, diarrhea, and abdominal pain, some of these symptoms may be associated ...
Accurately segmenting and individualizing cells in scanning electron microscopy (SEM) images is a highly promising technique for elucidating tissue architecture in oncology. While current artificial intelligence (AI)-based methods are effective, erro...
Signaling pathway components are well studied, but how they mediate cell-type-specific transcription responses is an unresolved problem. Using the Hippo pathway in mouse trophoblast stem cells as a model, we show that the DNA binding of signaling eff...
Synthetic cells (SCs), developed through bottom-up synthetic biology, hold great potential for biomedical applications, with the promise of replacing malfunctioning natural cells and treating diseases with spatiotemporal control. Currently, most SC s...
SIGNIFICANCE: High-resolution optical imaging at significant depths is challenging due to scattering, which impairs image quality in living matter with complex structures. We address the need for improved imaging techniques in deep tissues.
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