Computer methods and programs in biomedicine
Jan 10, 2021
BACKGROUND AND OBJECTIVE: With the advancement of electron microscopy (EM) imaging technology, neuroscientists can investigate the function of various intracellular organelles, e.g, mitochondria, at nano-scale. Semantic segmentation of electron micro...
The intra-axonal water exchange time (τ), a parameter associated with axonal permeability, could be an important biomarker for understanding and treating demyelinating pathologies such as Multiple Sclerosis. Diffusion-Weighted MRI (DW-MRI) is sensiti...
International journal of molecular sciences
Sep 2, 2020
Plasma lipoproteins are important carriers of cholesterol and have been linked strongly to cardiovascular disease (CVD). Our study aimed to achieve fine-grained measurements of lipoprotein subpopulations such as low-density lipoprotein (LDL), lipopro...
Journal of chemical information and modeling
Mar 30, 2020
Despite significant advances in resolution, the potential for cryo-electron microscopy (EM) to be used in determining the structures of protein-drug complexes remains unrealized. Determination of accurate structures and coordination of bound ligands ...
IEEE journal of biomedical and health informatics
Dec 23, 2019
Delineation of mitochondria from electron microscopy (EM) images is crucial to investigate its morphology and distribution, which are directly linked to neural dysfunction. However, it is a challenging task due to the varied appearances, sizes and sh...
For many nanoparticle applications it is important to understand dispersion in liquids. For nanomedicinal and nanotoxicological research this is complicated by the often complex nature of the biological dispersant and ultimately this leads to severe ...
We present an Unsupervised Domain Adaptation strategy to compensate for domain shifts on Electron Microscopy volumes. Our method aggregates visual correspondences-motifs that are visually similar across different acquisitions-to infer changes on the ...
BACKGROUND: Standard segmentation of high-contrast electron micrographs (EM) identifies myelin accurately but does not translate easily into measurements of individual axons and their myelin, even in cross-sections of parallel fibers. We describe aut...
Reconstruction and annotation of volume electron microscopy data sets of brain tissue is challenging but can reveal invaluable information about neuronal circuits. Significant progress has recently been made in automated neuron reconstruction as well...
IEEE transactions on pattern analysis and machine intelligence
May 24, 2018
We present a method combining affinity prediction with region agglomeration, which improves significantly upon the state of the art of neuron segmentation from electron microscopy (EM) in accuracy and scalability. Our method consists of a 3D U-Net, t...
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