AIMC Topic: Microscopy, Fluorescence, Multiphoton
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Deep structural brain imaging via computational three-photon microscopy.
Journal of biomedical optics
Mar 29, 2025
SIGNIFICANCE: High-resolution optical imaging at significant depths is challenging due to scattering, which impairs image quality in living matter with complex structures. We address the need for improved imaging techniques in deep tissues.
A first explainable-AI-based workflow integrating forward-forward and backpropagation-trained networks of label-free multiphoton microscopy images to assess human biopsies of rare neuromuscular disease.
Computer methods and programs in biomedicine
Mar 21, 2025
BACKGROUND AND OBJECTIVE: Diagnosis of rare neuromuscular diseases often relies on muscle biopsy analysis, which varies based on the evaluator's experience. Advances in deep learning show promise in improving diagnostic accuracy by identifying standa...
Fast In Vivo Two-Photon Fluorescence Imaging via Lateral and Axial Resolution Restoration With Self-Supervised Learning.
Journal of biophotonics
Feb 5, 2025
Two-photon fluorescence (TPF) imaging opens a new avenue to achieve high resolution at extended penetration depths. However, it is difficult for conventional TPF imaging systems to simultaneously achieve high resolution and speed. In this work, we de...
Diagnosis of Fibrotic Interstitial Lung Diseases Based on the Combination of Label-Free Quantitative Multiphoton Fiber Histology and Machine Learning.
Laboratory investigation; a journal of technical methods and pathology
Dec 13, 2024
Interstitial lung disease (ILD), characterized by inflammation and fibrosis, often suffers from low diagnostic accuracy and consistency. Traditional hematoxylin and eosin (H&E) staining primarily reveals cellular inflammation with limited detail on f...
Measuring Metabolic Changes in Cancer Cells Using Two-Photon Fluorescence Lifetime Imaging Microscopy and Machine-Learning Analysis.
Journal of biophotonics
Nov 25, 2024
Two-photon (2P) fluorescence lifetime imaging microscopy (FLIM) was used to track cellular metabolism with drug treatment of auto-fluorescent coenzymes NAD(P)H and FAD in living cancer cells. Simultaneous excitation at 800 nm of both coenzymes was co...
AutoLNMNet: Automated Network for Estimating Lymph-Node Metastasis in EGC Using a Pyramid Vision Transformer and Data Derived From Multiphoton Microscopy.
Microscopy research and technique
Oct 1, 2024
Lymph-node status is important in decision-making during early gastric cancer (EGC) treatment. Currently, endoscopic submucosal dissection is the mainstream treatment for EGC. However, it is challenging for even experienced endoscopists to accurately...
AI-based digital pathology provides newer insights into lifestyle intervention-induced fibrosis regression in MASLD: An exploratory study.
Liver international : official journal of the International Association for the Study of the Liver
Jul 4, 2024
BACKGROUND AND AIMS: Lifestyle intervention is the mainstay of therapy for metabolic dysfunction-associated steatohepatitis (MASH), and liver fibrosis is a key consequence of MASH that predicts adverse clinical outcomes. The placebo response plays a ...
Intravital deep-tumor single-beam 3-photon, 4-photon, and harmonic microscopy.
eLife
Feb 15, 2022
Three-photon excitation has recently been demonstrated as an effective method to perform intravital microscopy in deep, previously inaccessible regions of the mouse brain. The applicability of 3-photon excitation for deep imaging of other, more heter...
Early Emergence of Solid Shape Coding in Natural and Deep Network Vision.
Current biology : CB
Oct 22, 2020
Area V4 is the first object-specific processing stage in the ventral visual pathway, just as area MT is the first motion-specific processing stage in the dorsal pathway. For almost 50 years, coding of object shape in V4 has been studied and conceived...
Mu-net: Multi-scale U-net for two-photon microscopy image denoising and restoration.
Neural networks : the official journal of the International Neural Network Society
Jan 31, 2020
Advances in two two-photon microscopy (2PM) have made three-dimensional (3D) neural imaging of deep cortical regions possible. However, 2PM often suffers from poor image quality because of various noise factors, including blur, white noise, and photo...
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