The spread of early-stage (T1 and T2) adenocarcinomas to locoregional lymph nodes is a key event in disease progression of colorectal cancer (CRC). The cellular mechanisms behind this event are not completely understood and existing predictive biomar...
Red blood cells (RBCs) must be highly deformable to transit through the microvasculature to deliver oxygen to tissues. The loss of RBC deformability resulting from pathology, natural aging, or storage in blood bags can impede the proper function of t...
Applications of deep learning and other artificial intelligence techniques play an increasing role in pathological research. In contrast to research, applications in clinical routine are rare so far, although the first certified solutions have alread...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 8, 2021
This interdisciplinary work focuses on the interest of a new auto-encoder for supervised classification of live cell populations growing in a thermostated imaging station and acquired by a Quantitative Phase Imaging (QPI) camera. This type of camera ...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 8, 2021
Caenorhabditis elegans (C. elegans) is a popular and excellent model for studies of aging due to its short lifespan. Methods for precisely measuring the physiological age of C. elegans are critically needed, especially for antiaging drug screening an...
Fourier ptychographic microscopy (FPM) is a computational imaging technology for large field-of-view, high resolution and quantitative phase imaging. In FPM, low-resolution intensity images captured with angle-varying illumination are synthesized in ...
In preclinical research, histology images are produced using powerful optical microscopes to digitize entire sections at cell scale. Quantification of stained tissue relies on machine learning driven segmentation. However, such methods require multip...
Introduction White blood cells (WBCs) are immunity cells which fight against viruses and bacteria in the human body. Microscope images of captured WBCs for processing and analysis are important to interpret the body condition. At present, there is no...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Nov 7, 2021
Rapid and high-resolution histological imaging with minimal tissue preparation has long been a challenging and yet captivating medical pursuit. Here, the authors propose a promising and transformative histological imaging method, termed computational...
Genome editing simplifies the generation of new animal models for congenital disorders. However, the detailed and unbiased phenotypic assessment of altered embryonic development remains a challenge. Here, we explore how deep learning (U-Net) can auto...
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