AIMC Topic: Models, Animal

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Direct Comparison of the Prediction of the Unbound Brain-to-Plasma Partitioning Utilizing Machine Learning Approach and Mechanistic Neuropharmacokinetic Model.

The AAPS journal May 18, 2021
The mechanistic neuropharmacokinetic (neuroPK) model was established to predict unbound brain-to-plasma partitioning (K) by considering in vitro efflux activities of multiple drug resistance 1 (MDR1) and breast cancer resistance protein (BCRP). Herei...
Blood-Brain Barrier Animals Male Rats Machine Learning Datasets as Topic Models, Animal ATP Binding Cassette Transporter, Subfamily B ATP Binding Cassette Transporter, Subfamily G, Member 2 Predictive Value of Tests Dogs Models, Biological Madin Darby Canine Kidney Cells
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Deep learning in forensic gunshot wound interpretation-a proof-of-concept study.

International journal of legal medicine Apr 6, 2021
While the applications of deep learning are considered revolutionary within several medical specialties, forensic applications have been scarce despite the visual nature of the field. For example, a forensic pathologist may benefit from deep learning...
Wounds, Gunshot Forensic Pathology Forensic Ballistics Neural Networks, Computer Swine Animals Deep Learning Models, Animal Proof of Concept Study
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An efficient method for building a database of diatom populations for drowning site inference using a deep learning algorithm.

International journal of legal medicine Jan 3, 2021
Seasonal or monthly databases of the diatom populations in specific bodies of water are needed to infer the drowning site of a drowned body. However, existing diatom testing methods are laborious, time-consuming, and costly and usually require specif...
Artificial Intelligence Databases, Factual Sensitivity and Specificity Animals Neural Networks, Computer Forensic Pathology Drowning Lung China Rats Seasons Rats, Sprague-Dawley Rivers Models, Animal Diatoms
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A goal-driven modular neural network predicts parietofrontal neural dynamics during grasping.

Proceedings of the National Academy of Sciences of the United States of America Nov 30, 2020
One of the primary ways we interact with the world is using our hands. In macaques, the circuit spanning the anterior intraparietal area, the hand area of the ventral premotor cortex, and the primary motor cortex is necessary for transforming visual ...
Hand Arm Models, Animal Motor Activity Animals Male Models, Neurological Hand Strength Frontal Lobe Parietal Lobe Macaca mulatta Neural Networks, Computer Female
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Artificial Intelligence Analysis of Magnetic Particle Imaging for Islet Transplantation in a Mouse Model.

Molecular imaging and biology Aug 24, 2020
PURPOSE: Current approaches to quantification of magnetic particle imaging (MPI) for cell-based therapy are thwarted by the lack of reliable, standardized methods of segmenting the signal from background in images. This calls for the development of a...
Kidney Magnetic Phenomena Molecular Imaging Models, Animal Islets of Langerhans Transplantation Islets of Langerhans Tomography, X-Ray Computed Animals Imaging, Three-Dimensional Mice Humans Artificial Intelligence Algorithms
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Lightweight Learning-Based Automatic Segmentation of Subretinal Blebs on Microscope-Integrated Optical Coherence Tomography Images.

American journal of ophthalmology Jul 21, 2020
PURPOSE: Subretinal injections of therapeutics are commonly used to treat ocular diseases. Accurate dosing of therapeutics at target locations is crucial but difficult to achieve using subretinal injections due to leakage, and there is no method avai...
ROC Curve Imaging, Three-Dimensional Tomography, Optical Coherence Retina Models, Animal Algorithms Injections, Intraocular Animals Subretinal Fluid Swine Ringer's Lactate Deep Learning
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A Novel Robotic Endoscopic Device Used for Operative Hysteroscopy.

Journal of minimally invasive gynecology Jun 12, 2020
To trial the use of a novel endoscopic robot that functions using concentric tube robots, enabling 2-handed surgery in small spaces, in a bioengineering laboratory. This was a feasibility study of the endoscopic robot for hysteroscopic applications, ...
Swine Robotics Robotic Surgical Procedures Device Removal Feasibility Studies Inventions Models, Animal Hysteroscopy Humans Female Endoscopy Animals Polyps Gynatresia Intrauterine Devices Uterine Diseases
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Automated detection of the head-twitch response using wavelet scalograms and a deep convolutional neural network.

Scientific reports May 20, 2020
Hallucinogens induce the head-twitch response (HTR), a rapid reciprocal head movement, in mice. Although head twitches are usually identified by direct observation, they can also be assessed using a head-mounted magnet and a magnetometer. Procedures ...
Head Movements Reproducibility of Results Behavior Observation Techniques Sensitivity and Specificity Hallucinogens Magnetometry Male Animals Models, Animal Magnets Mice Behavior, Animal Support Vector Machine Drug Evaluation, Preclinical
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A Deep Learning Approach for Automated Sleep-Wake Scoring in Pre-Clinical Animal Models.

Journal of neuroscience methods Mar 2, 2020
BACKGROUND: Experimental investigation of sleep-wake dynamics in animals is an important part of pharmaceutical development. Typically, it involves recording of electroencephalogram, electromyogram, locomotor activity, and electrooculogram. Visual id...
Sleep Models, Animal Deep Learning Sleep Stages Neural Networks, Computer Mice Algorithms Rats Animals Dogs
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Advantages of aquatic animals as models for bio-inspired drones over present AUV technology.

Bioinspiration & biomimetics Feb 7, 2020
Robotic systems are becoming more ubiquitous, whether on land, in the air, or in water. In the aquatic realm, aquatic drones including ROVs (remotely operated vehicles) and AUVs (autonomous underwater vehicles) have opened new opportunities to invest...
Equipment Failure Analysis Aquatic Organisms Biomimetics Swimming Models, Animal Computer Simulation Animals Robotics Remote Sensing Technology Equipment Design
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