Prior to clinical development, a comprehensive pharmacokinetic characterization of a novel drug is required to understand its exposure at the site of action and elimination. Accordingly, assays and animal pharmacokinetic studies are regularly employ...
Predictive modeling of new biochemical systems with small data is a great challenge. To fill this gap, transfer learning, a subdomain of machine learning that serves to transfer knowledge from a generalized model to a more domain-specific model, prov...
Understanding the human motor control strategy during physical interaction tasks is crucial for developing future robots for physical human-robot interaction (pHRI). In physical human-human interaction (pHHI), small interaction forces are known to co...
The active assembly of molecules by nanorobots has advanced greatly since “molecular manufacturing”—that is, the use of nanoscale tools to build molecular structures—was proposed. In contrast to a catalyst, which accelerates a reaction by smoothing t...
Physiologically based pharmacokinetic (PBPK) modeling has the potential to play significant roles in estimating internal chemical exposures. The three major PBPK model input parameters (i.e., absorption rate constants, volumes of the systemic circula...
It is widely thought that individuals age at different rates. A method that measures "physiological age" or physiological aging rate independent of chronological age could therefore help elucidate mechanisms of aging and inform an individual's risk o...
BACKGROUND: Kidney allograft failure is a common cause of end-stage renal disease. We aimed to develop a dynamic artificial intelligence approach to enhance risk stratification for kidney transplant recipients by generating continuously refined predi...
In this paper, we perform experimental investigations of the aerodynamic characteristics due to wing clapping in bio-inspired flying robots; i.e., micro-air-vehicles (MAVs) that fly by flapping their wings. For this purpose, four flapping MAV models ...
Mathematical models in epidemiology are an indispensable tool to determine the dynamics and important characteristics of infectious diseases. Apart from their scientific merit, these models are often used to inform political decisions and interventio...
Applied biochemistry and biotechnology
Oct 20, 2021
In vivo micronucleus assay is the widely used genotoxic test to determine the extent of chromosomal aberrations caused by the chemicals in human beings, which plays a significant role in the drug discovery paradigm. To reduce the uncertainties of the...
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