AIMC Topic: Nanoparticles
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Exploration of the nanomedicine-design space with high-throughput screening and machine learning.
Nature biomedical engineering
Feb 18, 2019
Only a tiny fraction of the nanomedicine-design space has been explored, owing to the structural complexity of nanomedicines and the lack of relevant high-throughput synthesis and analysis methods. Here, we report a methodology for determining struct...
Synthesis of chitosan nanoparticles, chitosan-bulk, chitosan nanoparticles conjugated with glutaraldehyde with strong anti-cancer proliferative capabilities.
Artificial cells, nanomedicine, and biotechnology
Jan 31, 2019
In recent years, natural and synthetic polymers have attracted much attention due to their great potentials in medical science. In the present study, we have investigated the effect of chitosan-bulk (Ch-bulk), chitosan nanoparticles (ChNP), chitosan ...
Quantitative design rules for protein-resistant surface coatings using machine learning.
Scientific reports
Jan 22, 2019
Preventing biological contamination (biofouling) is key to successful development of novel surface and nanoparticle-based technologies in the manufacturing industry and biomedicine. Protein adsorption is a crucial mediator of the interactions at the ...
Fluorescent silicon nanoparticles inhibit the amyloid fibrillation of insulin.
Journal of materials chemistry. B
Jan 21, 2019
Amyloid fibrillation of proteins is likely a key factor leading to the development of amyloidosis-associated diseases. Inhibiting amyloid fibrillation has become a crucial therapeutic strategy. Water-soluble, fluorescent silicon nanoparticles (SiNPs)...
Manganese oxide nanoparticles induce genotoxicity and DNA hypomethylation in the moss Physcomitrella patens.
Mutation research. Genetic toxicology and environmental mutagenesis
Dec 18, 2018
The genotoxicity of nanoparticles is a major concern for nano-safety appraisal in the bryophytes as they are the primary colonizers of bare land, indicators of atmospheric pollution and excellent accumulators of trace metals. The present study for th...
Using artificial neural network to investigate physiological changes and cerium oxide nanoparticles and cadmium uptake by Brassica napus plants.
Environmental pollution (Barking, Essex : 1987)
Dec 12, 2018
Heavy metals and emerging engineered nanoparticles (ENPs) are two current environmental concerns that have attracted considerable attention. Cerium oxide nanoparticles (CeONPs) are now used in a plethora of industrial products, while cadmium (Cd) is ...
Etching reaction-based photoelectrochemical immunoassay of aflatoxin B in foodstuff using cobalt oxyhydroxide nanosheets-coating cadmium sulfide nanoparticles as the signal tags.
Analytica chimica acta
Dec 7, 2018
A new split-type photoelectrochemical (PEC) immunosensing platform was designed for sensitive detection of aflatoxin B (AFB) in foodstuffs, coupling with enzymatic hydrolysate-triggered etching reaction of cobalt oxyhydroxide (CoOOH) on cadmium sulfi...
Investigation of magnetic silica with thermoresponsive chitosan coating for drug controlled release and magnetic hyperthermia application.
Materials science & engineering. C, Materials for biological applications
Nov 30, 2018
In this study, a drug delivery system for chemo-hyperthermia applications is proposed and fabricated. The delivery system consists of magnetic-silica (MagSi) particles being encapsulated within a pH/thermo-responsive chitosan‑g‑N‑isopropylacrylamide ...
Dopamine-functionalized upconversion nanoparticles as fluorescent sensors for organophosphorus pesticide analysis.
Talanta
Nov 30, 2018
Organophosphorus pesticide (OP) residues in agricultural products, herbal medicines and environment have attracted increasing concerns because they cause high healthy risk. Herein, a tyrosinase-mediated photoinduced electron transfer system was const...
Molecular structure regulation and enzyme cascade signal amplification strategy for upconversion ratiometric luminescent and colorimetric alkaline phosphatase detection.
Analytica chimica acta
Nov 15, 2018
Herein, molecular structure regulation and enzyme cascade signals amplification (MRECAmp) strategy was proposed to construct a novel upconversion ratiometric fluorescence and colorimetric dual-readout assay platform for highly sensitive and selective...
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