AIMC Topic: Nanoparticles

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Bioconjugates of photon-upconversion nanoparticles with antibodies for the detection of prostate-specific antigen and p53 in heterogeneous and homogeneous immunoassays.

Nanoscale
Sensitive immunoassays for the detection of tumor biomarkers play an important role in the early diagnosis and therapy of cancer. Using luminescent nanomaterials as labels can significantly improve immunoassay performance, especially in terms of sens...

Exploiting Metabolic Defects in Glioma with Nanoparticle-Encapsulated NAMPT Inhibitors.

Molecular cancer therapeutics
The treatment of primary central nervous system tumors is challenging due to the blood-brain barrier and complex mutational profiles, which is associated with low survival rates. However, recent studies have identified common mutations in gliomas [is...

Understanding the Manufacturing Process of Lipid Nanoparticles for mRNA Delivery Using Machine Learning.

Chemical & pharmaceutical bulletin
Lipid nanoparticles (LNPs), used for mRNA vaccines against severe acute respiratory syndrome coronavirus 2, protect mRNA and deliver it into cells, making them an essential delivery technology for RNA medicine. The LNPs manufacturing process consists...

Application of acoustic spectroscopy and neural networks to on-line size measurement of pharmaceutical nanocrystals.

The Journal of the Acoustical Society of America
Acoustic spectroscopy and neural networks (NNs) are applied to on-line real-time measurement of particle size distribution (PSD) during wet milling of pharmaceutical nanocrystals. A method for modeling the relationship between acoustic attenuation sp...

Machine learning algorithms to control concentrations of carbon nanocomplexes in a biological medium via optical absorption spectroscopy: how to choose and what to expect?

Applied optics
A solution of spectroscopic inverse problems, implying determination of target parameters of the research object via analysis of spectra of various origins, is an overly complex task, especially in case of strong variability of the research object. O...

Choline Proline Ionic Liquid-Functionalized FeO@SiO Nanoparticle Magnetic Solid Phase Extraction Coupled with High-Performance Liquid Chromatography for Analysis of Allura Red in Lipstick Sample.

Journal of cosmetic science
A separation/analysis of allura red based on magnetic solid-phase extraction-high-performance liquid chromatography was developed. The extractant was prepared by functionalizing choline proline ionic liquid on FeO@SiO(FeO@SiO@[Ch][Pro]). Infl uences ...

Improvement of solubility and dissolution of ebastine by fabricating phosphatidylcholine/ bile salt bilosomes.

Pakistan journal of pharmaceutical sciences
Although ebastine (EBT) can impede histamine-induced skin allergic reaction and persuade long acting selective H1 receptor antagonistic effects but its poor water solubility circumscribed its clinical application. The main objective of this research ...

Artificial neural networks for the inverse design of nanoparticles with preferential nano-bio behaviors.

The Journal of chemical physics
Safe and efficient use of ultrasmall nanoparticles (NPs) in biomedicine requires numerous independent conditions to be met, including colloidal stability, selectivity for proteins and membranes, binding specificity, and low affinity for plasma protei...

Sustainable manufacturing of sensors onto soft systems using self-coagulating conductive Pickering emulsions.

Science robotics
Compliant sensors based on composite materials are necessary components for geometrically complex systems such as wearable devices or soft robots. Composite materials consisting of polymer matrices and conductive fillers have facilitated the manufact...

Designing nanoparticle release systems for drug-vitamin cancer co-therapy with multiplicative perturbation-theory machine learning (PTML) models.

Nanoscale
Nano-systems for cancer co-therapy including vitamins or vitamin derivatives have showed adequate results to continue with further research studies to better understand them. However, the number of different combinations of drugs, vitamins, nanoparti...