Biological psychiatry. Cognitive neuroscience and neuroimaging
Jun 21, 2019
BACKGROUND: The field of psychiatry has long sought biomarkers that can objectively diagnose patients, predict treatment response, or identify individuals at risk of illness onset. However, reliable psychiatric biomarkers have yet to emerge. The rece...
Carotid-artery atherosclerosis (CA) contributes significantly to overall morbidity and mortality in ischemic stroke. We propose a machine learning technique to automatically identify subjects with CA from a heterogeneous cohort of magnetic resonance ...
BACKGROUND: Human cortical primary sulci are relatively stable landmarks and commonly observed across the population. Despite their stability, the primary sulci exhibit phenotypic variability.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Jun 11, 2019
INTRODUCTION: It is challenging at baseline to predict when and which individuals who meet criteria for mild cognitive impairment (MCI) will ultimately progress to Alzheimer's disease (AD) dementia.
Machine learning is increasingly being applied to neuroimaging data. However, most machine learning algorithms have not been designed to accommodate neuroimaging data, which typically has many more data points than subjects, in addition to multicolli...
Longitudinal imaging biomarkers are invaluable for understanding the course of neurodegeneration, promising the ability to track disease progression and to detect disease earlier than cross-sectional biomarkers. To properly realize their potential, b...
AJNR. American journal of neuroradiology
May 30, 2019
BACKGROUND AND PURPOSE: Accurate automated infarct segmentation is needed for acute ischemic stroke studies relying on infarct volumes as an imaging phenotype or biomarker that require large numbers of subjects. This study investigated whether an ens...
AJNR. American journal of neuroradiology
May 30, 2019
BACKGROUND AND PURPOSE: 3D reconstruction of a targeted area ("safe" triangle and Kambin triangle) may benefit the viability assessment of transforaminal epidural steroid injection, especially at the L5/S1 level. However, manual segmentation of lumbo...
RATIONALE: The impact of neuroscience-based approaches for psychiatry on pragmatic clinical decision-making has been limited. Although neuroscience has provided insights into basic mechanisms of neural function, these insights have not improved the a...
BACKGROUND: Hippocampus is one of the first structures affected by neurodegenerative diseases such as Alzheimer's disease (AD) and mild cognitive impairment (MCI). Hippocampal atrophy can be evaluated in terms of hippocampal volumes and shapes using ...
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