Non-manifesting carriers (NMC) of the G2019S mutation in the LRRK2 gene represent an "at risk" group for future development of Parkinson's disease (PD) and have demonstrated task related fMRI changes. However, resting-state networks have received les...
IEEE transactions on bio-medical engineering
Feb 18, 2019
The assessment of Parkinson's disease (PD) poses a significant challenge, as it is influenced by various factors that lead to a complex and fluctuating symptom manifestation. Thus, a frequent and objective PD assessment is highly valuable for effecti...
BACKGROUND: Postural instability is a common disorder in Parkinson's disease (PD). The aim of this study was to evaluate stance stability of the subjects at the early stage of PD with both linear and nonlinear approaches. Moreover, this study aimed t...
BACKGROUND: Robot-assisted gait training (RAGT) was developed to restore gait function by promoting neuroplasticity through repetitive locomotor training and has been utilized in gait training. However, contradictory outcomes of RAGT have been report...
Neural networks : the official journal of the International Neural Network Society
Jan 6, 2019
Parkinson's disease (PD) is a common neurodegenerative disorder that affects human's quality of life, especially leading to locomotor deficits such as postural instability and gait disturbances. Gait signal is one of the best features to characterize...
AMIA ... Annual Symposium proceedings. AMIA Symposium
Dec 5, 2018
Parkinson's Disease (PD) is one of the most prevalent neurodegenerative diseases that affects tens of millions of Americans. PD is highly progressive and heterogeneous. Quite a few studies have been conducted in recent years on predictive or disease ...
IEEE transactions on bio-medical engineering
Nov 5, 2018
As the collection of mobile health data becomes pervasive, missing data can make large portions of datasets inaccessible for analysis. Missing data has shown particularly problematic for remotely diagnosing and monitoring Parkinson's disease (PD) usi...
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has shown clinical potential for relieving the motor symptoms of advanced Parkinson's disease. While accurate localization of the STN is critical for consistent across-patients effective D...
European journal of physical and rehabilitation medicine
Oct 29, 2018
BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disorder causing progressive gait disability. Although robot-assisted gait training (RAGT) using the Lokomat device has been demonstrated to improve gait in PD, it is not clear what the best...
Machine learning and data mining approaches are being successfully applied to different fields of life sciences for the past 20 years. Medicine is one of the most suitable application domains for these techniques since they help model diagnostic info...
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