BACKGROUND: With the rapid development of digital biomarkers in Parkinson disease (PD) research, it has become increasingly important to explore the current research trends and key areas of focus.
INTRODUCTION: Deep brain stimulation (DBS) is a proven effective treatment for Parkinson's disease (PD). However, titrating DBS stimulation parameters is a labourious process and requires frequent hospital visits. Additionally, its current applicatio...
Studies in health technology and informatics
May 15, 2025
This study explored the perspectives of people with Parkinson's disease (PwP) involved in the co-design of AI tools for PD care. The aim was to understand PwP perspectives on AI tools and identify factors influencing their engagement. A qualitative t...
This study investigates the classification of individuals as healthy or at risk of Parkinson's disease using machine learning (ML) models, focusing on the impact of dataset size and preprocessing techniques on model performance. Four datasets are cre...
International journal of molecular sciences
May 7, 2025
Parkinson's disease (PD) is a complex neurodegenerative disorder lacking effective disease-modifying treatments. In this study, we integrated large-scale protein-protein interaction networks with a multi-modal graph neural network (GNN) to identify a...
Parkinson's disease (PD) remains a condition without a cure, though its early manifestations can be managed effectively by medical professionals. This underscores the significance of early detection of PD. It has been widely demonstrated that handwri...
BACKGROUND: Postural instability and gait difficulties are key symptoms of Parkinson's disease (PD), elevating the risk of falls substantially. Falls afflict 35% to 90% of PD patients, representing a major challenge in managing the condition. Accurat...
IMPORTANCE: Magnetic resonance imaging (MRI) paired with appropriate disease-specific machine learning holds promise for the clinical differentiation of Parkinson disease (PD), multiple system atrophy (MSA) parkinsonian variant, and progressive supra...
MOTIVATION: Enabling clinicians and researchers to directly interact with global genomic data resources by removing technological barriers is vital for medical genomics. AskBeacon enables large language models (LLMs) to be applied to securely shared ...
BACKGROUND: The high heterogeneity of Parkinson's disease (PD) hinders personalized interventions. Brain structure reflects damage and neuroplasticity and is one of the biological bases of symptomatology. Subtyping PD in the framework of brain struct...
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