AIMC Topic: Periodontitis

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Exploring hypoxia- and cuproptosis-related biomarkers in periodontitis based on transcriptome and single-cell analysis.

Clinical oral investigations
BACKGROUND: Periodontitis (PD) is a chronic, multifactorial inflammatory disorder characterized by the progressive destruction of periodontal tissues. Increasing evidence indicates that the dysregulation of hypoxia-related genes (HRGs) plays a pivota...

Relevance of Prognosis Tools in Periodontitis: A Systematic Review.

Oral health & preventive dentistry
PURPOSE: Tooth-level prognostic systems can be used for treatment planning and help to identify teeth at risk of being lost over time. However, several sets of criteria were proposed to estimate tooth prognosis in the context of periodontitis patient...

Integrating bulk and single-cell RNA sequencing data to dissect genetic links between periodontitis and obstructive sleep apnea.

Sleep & breathing = Schlaf & Atmung
PURPOSE: Periodontitis (PD) and obstructive sleep apnea (OSA) are widespread conditions with profound health consequences. Increasing evidence suggests shared pathophysiological mechanisms between PD and OSA, prompting this study to explore their gen...

Single-cell RNA-seq combined with bulk RNA-seq analysis identifies necroptosis-related genes as therapeutic targets for periodontitis.

BMC medical genomics
BACKGROUND: Necroptosis, a regulated form of programmed cell death, exacerbates inflammatory responses by releasing damage-associated molecular patterns and inflammatory factors. However, the specific mechanisms underlying necroptosis in periodontiti...

Development and validation of artificial intelligence models for automated periodontitis staging and grading using panoramic radiographs.

BMC oral health
BACKGROUND: Periodontal diseases are common chronic conditions that can lead to tooth loss and systemic complications if not diagnosed and treated promptly. The 2017 classification by the American Academy of Periodontology highlights the need for eff...

Single-cell RNA sequencing and Mendelian randomization, revealing molecular mechanisms and causal correlation of immune-related genes in periodontitis.

Scientific reports
The immune system has been linked to periodontitis risk in oral inflammation and systemic consequences. Specifically, this study investigated whether hub genes were associated with immune cells via integrating single-cell RNA sequencing (scRNA-seq) a...

Discovering periodontitis biomarkers and therapeutic targets through bioinformatics and ensemble learning analysis.

Scientific reports
Periodontitis, a prevalent inflammatory disease, leads to the progressive destruction of periodontal tissues and poses significant systemic health risks. Despite its widespread impact, the molecular mechanisms driving periodontitis remain poorly unde...

A Machine Learning-Driven Cyclic Optimizing Strategy for the Construction of Paper-Based Microfluidic Devices in the Early Diagnosis of Periodontitis.

ACS sensors
The lack of effective optimization strategies hinders the optimal performance of paper-based microfluidic analytical devices (μPADs). In this work, a Machine Learning-driven Computer vision-BP Neural Networks-Genetic Algorithm-based Cyclic Optimizing...

Revealing potential interfering genes between abdominal aortic aneurysm and periodontitis through machine learning and bioinformatics analysis.

PloS one
This study aimed to identify potential interacting genes between abdominal aortic aneurysm (AAA) and periodontitis. To achieve this, we obtained datasets of AAA and periodontitis from the GEO database, conducted differential analysis on the AAA datas...