AIMC Topic: Positron-Emission Tomography

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Ensemble of neural networks for 3D position estimation in monolithic PET detectors.

Physics in medicine and biology
We propose an ensemble of multilayer feedforward neural networks to estimate the 3D position of photoelectric interactions in monolithic detectors. The ensemble is trained with data generated from optical Monte Carlo simulations only. The originality...

Image reconstruction for positron emission tomography based on patch-based regularization and dictionary learning.

Medical physics
PURPOSE: Positron emission tomography (PET) is an important tool for nuclear medical imaging. It has been widely used in clinical diagnosis, scientific research, and drug testing. PET is a kind of emission computed tomography. Its basic imaging princ...

Three-dimensional convolutional neural networks for simultaneous dual-tracer PET imaging.

Physics in medicine and biology
Dual-tracer positron emission tomography (PET) is a promising technique to measure the distribution of two tracers in the body by a single scan, which can improve the clinical accuracy of disease diagnosis and can also serve as a research tool for sc...

Quantifying brain metabolism from FDG-PET images into a probability of Alzheimer's dementia score.

Human brain mapping
F-fluorodeoxyglucose positron emission tomography (FDG-PET) enables in-vivo capture of the topographic metabolism patterns in the brain. These images have shown great promise in revealing the altered metabolism patterns in Alzheimer's disease (AD). ...

Range and dose verification in proton therapy using proton-induced positron emitters and recurrent neural networks (RNNs).

Physics in medicine and biology
Online proton range/dose verification based on measurements of proton-induced positron emitters is a promising strategy for quality assurance in proton therapy. Because of the nonlinear correlation between the dose distribution and the activity distr...

PET image denoising using unsupervised deep learning.

European journal of nuclear medicine and molecular imaging
PURPOSE: Image quality of positron emission tomography (PET) is limited by various physical degradation factors. Our study aims to perform PET image denoising by utilizing prior information from the same patient. The proposed method is based on unsup...

Predicting PET-derived demyelination from multimodal MRI using sketcher-refiner adversarial training for multiple sclerosis.

Medical image analysis
Multiple sclerosis (MS) is the most common demyelinating disease. In MS, demyelination occurs in the white matter of the brain and in the spinal cord. It is thus essential to measure the tissue myelin content to understand the physiopathology of MS, ...

An investigation of quantitative accuracy for deep learning based denoising in oncological PET.

Physics in medicine and biology
Reducing radiation dose is important for PET imaging. However, reducing injection doses causes increased image noise and low signal-to-noise ratio (SNR), subsequently affecting diagnostic and quantitative accuracies. Deep learning methods have shown ...

mDixon-Based Synthetic CT Generation for PET Attenuation Correction on Abdomen and Pelvis Jointly Using Transfer Fuzzy Clustering and Active Learning-Based Classification.

IEEE transactions on medical imaging
We propose a new method for generating synthetic CT images from modified Dixon (mDixon) MR data. The synthetic CT is used for attenuation correction (AC) when reconstructing PET data on abdomen and pelvis. While MR does not intrinsically contain any ...

Prediction of Chemotherapy Response of Osteosarcoma Using Baseline F-FDG Textural Features Machine Learning Approaches with PCA.

Contrast media & molecular imaging
PURPOSE: Patients with high-grade osteosarcoma undergo several chemotherapy cycles before surgical intervention. Response to chemotherapy, however, is affected by intratumor heterogeneity. In this study, we assessed the ability of a machine learning ...