BACKGROUND: Neoadjuvant therapy plays a pivotal role in breast cancer treatment, particularly for patients aiming to conserve their breast by reducing tumor size pre-surgery. The ultimate goal of this treatment is achieving a pathologic complete resp...
Despite the critical role of DNA methylation, clinical implementations harnessing its promise have not been described in acute myeloid leukemia. Utilizing DNA methylation from 3314 leukemia patient samples across 11 harmonized cohorts, we describe th...
Primary liver cancer is the sixth most commonly diagnosed cancer globally and the third leading cause of cancer-related deaths. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, and microvascular invasion (MVI) is a sign...
Basement membranes (BMs) and tumor-associated macrophages (TAMs) are crucial stromal components in pancreatic cancer (PC), critically influencing disease progression. Bulk and single-cell RNA-seq (scRNA-seq) data were acquired from publicly available...
O-glycosylation significantly influences cellular physiological processes and disease regulation by modulating the structure, function, and stability of proteins. However, there is a notable gap in research focusing on O-glycosylation in relation to ...
BACKGROUND: Static carcinoembryonic antigen (CEA) levels are well‑established prognostic markers in patients with gastric cancer, but the significance of their dynamic trajectories over time has rarely been reported.
BACKGROUND: Intensive care unit (ICU)-acquired weakness (ICUAW) is a prevalent complication in critically ill patients, marked by symmetrical respiratory and limb muscle weakness, which adversely affects long-term outcomes. Early identification of hi...
Alzheimer's disease (AD), a progressive neurodegenerative disorder, significantly impacts patient survival, prompting the need for accurate prognostic tools. Lifestyle factors and physical activity levels have been identified as critical modifiable r...
BACKGROUND: Incorporating initial serum chloride levels as a prognostic indicator in the intensive care environment has the potential to refine risk stratification and tailor treatment strategies, leading to more efficient use of clinical resources a...
Decision support systems (DSS) integrating artificial intelligence (AI) hold the potential to significantly enhance organizational decision-making performance and speed in areas such as prognostics in machine maintenance. A key issue for organization...
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