AIMC Topic: Prognosis

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[Current treatment status and future perspectives of advanced gallbladder cancer].

Zhonghua wai ke za zhi [Chinese journal of surgery]
Gallbladder cancer has an insidious onset,and most of the cases are in advanced stage at the time of diagnosis,with unfavorable prognosis. Radical surgery is the only potential curative method for gallbladder cancer at present,but radical surgery of ...

Explainable transformer-based deep survival analysis in childhood acute lymphoblastic leukemia.

Computers in biology and medicine
BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common type of leukemia among children and adolescents and can be life-threatening. The incidence of new cases has been increasing in recent years. Developing a predictive model to forecast t...

Computational pathology for breast cancer: Where do we stand for prognostic applications?

Breast (Edinburgh, Scotland)
The very early days of artificial intelligence (AI) in healthcare are behind us. AI is now spreading in the healthcare sector and is gradually being implemented in routine clinical practice. Driven by the increasing digitization of microscope slides,...

Predicting hepatocellular carcinoma response to TACE: A machine learning study based on 2.5D CT imaging and deep features analysis.

European journal of radiology
OBJECTIVES: Prior to the commencement of treatment, it is essential to establish an objective method for accurately predicting the prognosis of patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE). In this st...

A machine learning-derived angiogenesis signature for clinical prognosis and immunotherapy guidance in colon adenocarcinoma.

Scientific reports
Colon adenocarcinoma (COAD) is one of the most prevalent malignancies worldwide and its prognosis is extremely poor. Angiogenesis has been linked to clinical outcomes, tumor progression, and treatment sensitivity. However, the role of angiogenesis in...

Integrating bulk RNA-seq and scRNA-seq analyses with machine learning to predict platinum response and prognosis in ovarian cancer.

Scientific reports
Platinum-based therapy is an integral part of the standard treatment for ovarian cancer. However, despite extensive research spanning several decades, the identification of dependable predictive biomarkers for platinum response in clinical practice h...

An immunohistochemistry-based classification of colorectal cancer resembling the consensus molecular subtypes using convolutional neural networks.

Scientific reports
Colorectal cancer (CRC) represents a major global disease burden with nearly 1 million cancer-related deaths annually. TNM staging has served as the foundation for predicting patient prognosis, despite variation across staging groups. The consensus m...

Integration of Bulk RNA and Single-Cell Analyses Reveal Distinct Expression Patterns of Anoikis-Related Genes and the Immunosuppressive Role of NQO1 Macrophages in Hepatocellular Carcinoma.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Anoikis resistance plays a crucial role in the proliferation, metastasis, and invasion of hepatocellular carcinoma (HCC). However, the key genes involved remain to be identified. This study aimed to investigate the prognostic value and impact of anoi...

Integrated machine learning survival framework develops a prognostic model based on macrophage-related genes and programmed cell death signatures in a multi-sample Kidney renal clear cell carcinoma.

Cell biology and toxicology
BACKGROUND: Macrophages are closely associated with the progression of Kidney renal clear cell carcinoma (KIRC) and can influence programmed cell death (PCD) of tumour cells. To identify prognostic biomarkers for KIRC, it is essential to investigate ...

Identification of key genes regulating colorectal cancer stem cell characteristics by bioinformatics analysis.

Medicine
Cancer stem cells (CSCs), distinguished by their abilities to differentiate and self-renew, play a pivotal role in the progression of colorectal cancer (CRC). However, the mechanisms that sustain CSCs in CRC remain unclear. This study aimed to identi...