AIMC Topic: Rats, Sprague-Dawley
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Development and validation of a LC-MS/MS assay for quantification of cisplatin in rat plasma and urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Nov 23, 2016
Till date, no analytical method published to detect Cisplatin has been validated according to the U.S. Food and Drug Administration (FDA) guidance using liquid chromatography mass spectrometry (LC-MS/MS). We report, a validated LC-MS/MS method for qu...
Integration of metabolomics, lipidomics and clinical data using a machine learning method.
BMC bioinformatics
Nov 22, 2016
BACKGROUND: The recent pandemic of obesity and the metabolic syndrome (MetS) has led to the realisation that new drug targets are needed to either reduce obesity or the subsequent pathophysiological consequences associated with excess weight gain. Ce...
Dysfunction of endothelial progenitor cells in hyperlipidemic rats involves the increase of NADPH oxidase derived reactive oxygen species production.
Canadian journal of physiology and pharmacology
Oct 20, 2016
NADPH oxidase (NOX) is a major source of reactive oxygen species (ROS) in the body and it plays a key role in mediation of oxidative injury in the cardiovascular system. The purposes of this study are to evaluate the status of NOX in endothelial prog...
Brief isoflurane anaesthesia affects differential gene expression, gene ontology and gene networks in rat brain.
Behavioural brain research
Sep 19, 2016
Much is still unknown about the mechanisms of effects of even brief anaesthesia on the brain and previous studies have simply compared differential expression profiles with and without anaesthesia. We hypothesised that network analysis, in addition t...
Maze learning by a hybrid brain-computer system.
Scientific reports
Sep 13, 2016
The combination of biological and artificial intelligence is particularly driven by two major strands of research: one involves the control of mechanical, usually prosthetic, devices by conscious biological subjects, whereas the other involves the co...
Improved spatial accuracy of functional maps in the rat olfactory bulb using supervised machine learning approach.
NeuroImage
May 25, 2016
Functional MRI (fMRI) is a popular and important tool for noninvasive mapping of neural activity. As fMRI measures the hemodynamic response, the resulting activation maps do not perfectly reflect the underlying neural activity. The purpose of this wo...
Algorithms
Reproducibility of Results
Sensitivity and Specificity
Animals
Rats, Sprague-Dawley
Brain Mapping
Supervised Machine Learning
Image Interpretation, Computer-Assisted
Male
Spatio-Temporal Analysis
Rats
Olfactory Bulb
Magnetic Resonance Imaging
Pattern Recognition, Automated
Electric Stimulation
Smell
Image Enhancement
Optimized Repopulation of Tendon Hydrogel: Synergistic Effects of Growth Factor Combinations and Adipose-Derived Stem Cells.
Hand (New York, N.Y.)
Mar 15, 2016
Tendon-derived extracellular matrix (ECM) hydrogel has been shown to augment tendon healing in vivo. We hypothesized that reseeding of the gel with adipose-derived stem cells (ASCs) could further assist repopulation of the gel and that combinations ...
Intelligence-Augmented Rat Cyborgs in Maze Solving.
PloS one
Feb 9, 2016
Cyborg intelligence is an emerging kind of intelligence paradigm. It aims to deeply integrate machine intelligence with biological intelligence by connecting machines and living beings via neural interfaces, enhancing strength by combining the biolog...
Robotic Rehabilitator of the Rodent Upper Extremity: A System and Method for Assessing and Training Forelimb Force Production after Neurological Injury.
Journal of neurotrauma
Jan 18, 2016
Rodent models of spinal cord injury are critical for the development of treatments for upper limb motor impairment in humans, but there are few methods for measuring forelimb strength of rodents, an important outcome measure. We developed a novel rob...
Simultaneous quantification of 5 main components of Psoralea corylifolia L. in rats' plasma by utilizing ultra high pressure liquid chromatography tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Dec 30, 2015
Psoralea corylifolia L. has long been used in traditional Chinese medicine for treating and preventing many diseases. A group of flavonoid components are regarded as the active principals within the seeds. In this research, a rapid, accurate and sens...
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