AIMC Topic: RNA, Long Noncoding
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Stable solution to l -based robust inductive matrix completion and its application in linking long noncoding RNAs to human diseases.
BMC medical genomics
Dec 28, 2017
BACKGROUNDS: A large number of long intergenic non-coding RNAs (lincRNAs) are linked to a broad spectrum of human diseases. The disease association with many other lincRNAs still remain as puzzle. Validation of such links between the two entities thr...
A deep learning method for lincRNA detection using auto-encoder algorithm.
BMC bioinformatics
Dec 6, 2017
BACKGROUND: RNA sequencing technique (RNA-seq) enables scientists to develop novel data-driven methods for discovering more unidentified lincRNAs. Meantime, knowledge-based technologies are experiencing a potential revolution ignited by the new deep ...
DES-ncRNA: A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining.
RNA biology
Apr 7, 2017
Noncoding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long ncRNAs (lncRNAs), are important players in diseases and emerge as novel drug targets. Thus, unraveling the relationships between ncRNAs and other biomedical entities in cells are criti...
Analysis of cancer-related lncRNAs using gene ontology and KEGG pathways.
Artificial intelligence in medicine
Feb 13, 2017
BACKGROUND: Cancer is a disease that involves abnormal cell growth and can invade or metastasize to other tissues. It is known that several factors are related to its initiation, proliferation, and invasiveness. Recently, it has been reported that lo...
Predicting Long Noncoding RNA and Protein Interactions Using Heterogeneous Network Model.
BioMed research international
Dec 29, 2015
Recent study shows that long noncoding RNAs (lncRNAs) are participating in diverse biological processes and complex diseases. However, at present the functions of lncRNAs are still rarely known. In this study, we propose a network-based computational...
Microarray expression profiling and gene ontology analysis of long non-coding RNAs in spontaneously hypertensive rats and their potential roles in the pathogenesis of hypertension.
Molecular medicine reports
Nov 11, 2015
Long non-coding RNAs (lncRNAs) have been demonstrated to be significant in numerous biological processes. Hypertension is a form of cardiovascular disease with at least one billion cases worldwide. The present study sought to compare the differential...
LncRNA-ID: Long non-coding RNA IDentification using balanced random forests.
Bioinformatics (Oxford, England)
Aug 26, 2015
MOTIVATION: Long non-coding RNAs (lncRNAs), which are non-coding RNAs of length above 200 nucleotides, play important biological functions such as gene expression regulation. To fully reveal the functions of lncRNAs, a fundamental step is to annotate...
NetLnc: A Network-Based Computational Framework to Identify Immune Checkpoint-Related lncRNAs for Immunotherapy Response in Melanoma.
International journal of molecular sciences
May 9, 2025
Long non-coding RNAs (lncRNAs) could alter the tumor immune microenvironment and regulate the expression of immune checkpoints (ICPs) by regulating target genes in tumors. However, only a few lncRNAs have precise functions in immunity and potential f...
Analysis of RNA translation with a deep learning architecture provides new insight into translation control.
Nucleic acids research
Apr 10, 2025
Accurate annotation of coding regions in RNAs is essential for understanding gene translation. We developed a deep neural network to directly predict and analyze translation initiation and termination sites from RNA sequences. Trained with human tran...
Inter-view contrastive learning and miRNA fusion for lncRNA-protein interaction prediction in heterogeneous graphs.
Briefings in bioinformatics
Mar 4, 2025
Predicting long non-coding RNA (lncRNA)-protein interactions is essential for understanding biological processes and discovering new therapeutic targets. In this study, we propose a novel model based on inter-view contrastive learning and miRNA fusio...
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