AIMC Topic: RNA, Messenger
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DeepIRES: a hybrid deep learning model for accurate identification of internal ribosome entry sites in cellular and viral mRNAs.
Briefings in bioinformatics
Jul 25, 2024
The internal ribosome entry site (IRES) is a cis-regulatory element that can initiate translation in a cap-independent manner. It is often related to cellular processes and many diseases. Thus, identifying the IRES is important for understanding its ...
Unveil cis-acting combinatorial mRNA motifs by interpreting deep neural network.
Bioinformatics (Oxford, England)
Jun 28, 2024
SUMMARY: Cis-acting mRNA elements play a key role in the regulation of mRNA stability and translation efficiency. Revealing the interactions of these elements and their impact plays a crucial role in understanding the regulation of the mRNA translati...
Study of prognostic splicing factors in cancer using machine learning approaches.
Human molecular genetics
Jun 21, 2024
Splicing factors (SFs) are the major RNA-binding proteins (RBPs) and key molecules that regulate the splicing of mRNA molecules through binding to mRNAs. The expression of splicing factors is frequently deregulated in different cancer types, causing ...
m6ACali: machine learning-powered calibration for accurate m6A detection in MeRIP-Seq.
Nucleic acids research
May 22, 2024
We present m6ACali, a novel machine-learning framework aimed at enhancing the accuracy of N6-methyladenosine (m6A) epitranscriptome profiling by reducing the impact of non-specific antibody enrichment in MeRIP-Seq. The calibration model serves as a g...
DeepLocRNA: an interpretable deep learning model for predicting RNA subcellular localization with domain-specific transfer-learning.
Bioinformatics (Oxford, England)
Feb 1, 2024
MOTIVATION: Accurate prediction of RNA subcellular localization plays an important role in understanding cellular processes and functions. Although post-transcriptional processes are governed by trans-acting RNA binding proteins (RBPs) through intera...
An effective deep learning-based approach for splice site identification in gene expression.
Science progress
Jan 1, 2024
A crucial stage in eukaryote gene expression involves mRNA splicing by a protein assembly known as the spliceosome. This step significantly contributes to generating and properly operating the ultimate gene product. Since non-coding introns disrupt e...
Understanding the Manufacturing Process of Lipid Nanoparticles for mRNA Delivery Using Machine Learning.
Chemical & pharmaceutical bulletin
Jan 1, 2024
Lipid nanoparticles (LNPs), used for mRNA vaccines against severe acute respiratory syndrome coronavirus 2, protect mRNA and deliver it into cells, making them an essential delivery technology for RNA medicine. The LNPs manufacturing process consists...
[Experimental study of APB-DOCK8 transgenic tomato vaccine for caries prevention].
Shanghai kou qiang yi xue = Shanghai journal of stomatology
Dec 1, 2023
PURPOSE: To observe the anti-caries effect of transgenic tomato anti-caries vaccine after immunization with SD rats by gavage and to explore its immunity mechanism initially.
Changes of plasma Rap1A levels in patients with in-stent restenosis after percutaneous coronary intervention and the underlying mechanisms.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Nov 28, 2023
OBJECTIVES: Percutaneous coronary intervention (PCI) is one of the most important treatments for coronary artery disease (CAD). However, in-stent restenosis (ISR) after PCI is a serious complication without effective measures for prevention and treat...
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