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Schizophrenia

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Identifying Reproducibly Important EEG Markers of Schizophrenia with an Explainable Multi-Model Deep Learning Approach.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
The diagnosis of schizophrenia (SZ) can be challenging due to its diverse symptom presentation. As such, many studies have sought to identify diagnostic biomarkers of SZ using explainable machine learning methods. However, the generalizability of ide...

Classification of Schizophrenia using Intrinsic Connectivity Networks and Incremental Boosting Convolution Neural Networks.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
One of the key challenges in the use of resting brain functional magnetic resonance imaging (fMRI) network analysis for predicting mental illnesses such as schizophrenia (SZ) is the high noise levels variability among individuals including age, sex, ...

Neurofind: using deep learning to make individualised inferences in brain-based disorders.

Translational psychiatry
Within precision psychiatry, there is a growing interest in normative models given their ability to parse heterogeneity. While they are intuitive and informative, the technical expertise and resources required to develop normative models may not be a...

Identifying periphery biomarkers of first-episode drug-naïve patients with schizophrenia using machine-learning-based strategies.

Progress in neuro-psychopharmacology & biological psychiatry
Schizophrenia is a complex mental disorder. Accurate diagnosis and classification of schizophrenia has always been a major challenge in clinic due to the lack of biomarkers. Therefore, identifying molecular biomarkers, particularly in the peripheral ...

Multi-feature fusion method combining brain functional connectivity and graph theory for schizophrenia classification and neuroimaging markers screening.

Journal of psychiatric research
BACKGROUND: The abnormalities in brain functional connectivity (FC) and graph topology (GT) in patients with schizophrenia (SZ) are unclear. Researchers proposed machine learning algorithms by combining FC or GT to identify SZ from healthy controls. ...

Deep learning imputes DNA methylation states in single cells and enhances the detection of epigenetic alterations in schizophrenia.

Cell genomics
DNA methylation (DNAm) is a key epigenetic mark with essential roles in gene regulation, mammalian development, and human diseases. Single-cell technologies enable profiling DNAm at cytosines in individual cells, but they often suffer from low covera...

Predicting mental health disparities using machine learning for African Americans in Southeastern Virginia.

Scientific reports
This study examined mental health disparities among African Americans using AI and machine learning for outcome prediction. Analyzing data from African American adults (18-85) in Southeastern Virginia (2016-2020), we found Mood Affective Disorders we...

Efficient Neural Network Classification of Parkinson's Disease and Schizophrenia Using Resting-State EEG Data.

Brain topography
Timely identification of Parkinson's disease and schizophrenia is crucial for the effective management and enhancement of patients' quality of life. The utilization of electroencephalogram (EEG) monitoring applications has proven instrumental in diag...

miRNA-Based Diagnosis of Schizophrenia Using Machine Learning.

International journal of molecular sciences
Diagnostic practices for schizophrenia are unreliable due to the lack of a stable biomarker. However, machine learning holds promise in aiding in the diagnosis of schizophrenia and other neurological disorders. Dysregulated miRNAs were extracted from...

Predicting Diagnostic Progression to Schizophrenia or Bipolar Disorder via Machine Learning.

JAMA psychiatry
IMPORTANCE: The diagnosis of schizophrenia and bipolar disorder is often delayed several years despite illness typically emerging in late adolescence or early adulthood, which impedes initiation of targeted treatment.