Signal transduction and targeted therapy
Oct 13, 2025
Nearly 30% of patients with schizophrenia respond inadequately to current antipsychotics, with unclear markers and mechanisms of antipsychotic efficacy. A total of 208 patients with schizophrenia treated for 6 weeks with oral paliperidone were analyz...
INTRODUCTION: There are many barriers to mental health services, including cost and stigma. Even when individuals receive professional care, assessments are intermittent and may be limited in part by the cyclical nature of psychiatric symptoms. The h...
All medications currently used to treat schizophrenia, which exert their therapeutic effects by inhibiting dopaminergic neurotransmission, have their greatest efficacy against the positive symptoms of schizophrenia but have limited impact on negative...
Accurate differentiation of schizophrenia (SZ) and bipolar disorder (BD) is crucial for effective clinical management. However, current diagnostic methods, which rely heavily on subjective assessments, are prone to high rates of misdiagnosis. This st...
The multidimensional nature of schizophrenia requires a comprehensive exploration of the functional and structural brain networks. While prior research has provided valuable insights into these aspects, our study goes a step further to investigate th...
BACKGROUND: Social cognition is essential for daily functioning, as it influences quality of life, return to work, and interpersonal communication. While schizophrenia and autism spectrum disorder (ASD) have been the paradigmatic conditions in which ...
Psychiatric disorders lead to disability, premature mortality and economic burden, highlighting the urgent need for more effective treatments. The understanding of psychiatric disorders as conditions of large-scale brain networks has created new oppo...
Medical science monitor : international medical journal of experimental and clinical research
Sep 2, 2025
This review comprehensively examines the application and progress of functional near-infrared spectroscopy (fNIRS) in schizophrenia research. Schizophrenia is a complex neuropsychiatric disorder characterized by extensive dysfunction in the prefronta...
OBJECTIVE: This study aims to develop an objective and efficient diagnostic model for schizophrenia (SCZ) by integrating electroencephalogram (EEG) signals with deep learning techniques. Building on previous research, γ wave activity is selected as a...
Psychiatry lags in adopting etiological approaches to diagnosis, prognosis, and outcome prediction compared to the rest of medicine. Etiological factors such as childhood trauma (CHT), substance use (SU), and socioeconomic status (SES) significantly ...
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